Recombinant Human T-cell leukemia virus 1 Accessory protein p12I

in vitro E.coli expression system

中文名稱：

Recombinant Human T-cell leukemia virus 1 Accessory protein p12I
貨號：

CSB-CF315633HQG
說明書：

MSDS Datasheet
規格：
來源：

in vitro E.coli expression system
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

基因名：

N/A
Uniprot No.：

P0CK16
別名：

Accessory protein p12I
種屬：

Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1)
蛋白長度：

full length protein
表達區域：

1-99
氨基酸序列

MLFRLLSPLSPLALTALLLFLLSPGEVSGLLLRPLPAPCLLLFLPFQILSNLLFLLFLPL FFSLPLLLSPSLPITMRFPARWRFPPWRAPSQPAAAFLF
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

p12I is a modulator of T-lymphocyte proliferation and immune function and may contribute to establish a persistent infection. Binds and down-modulates cell surface expression of interleukin-2 receptors IL2RB and IL2RG. Also down-modulates cell surface MHC-I molecules by binding to free immature MHC-I heavy chains in the ER and targeting them to the proteasome for degradation. Binding to IL2RB mediates recruitment of JAK1 and JAK3. As a result of this interaction, p12I increases DNA-binding and transcriptional activity of STAT5.
亞細胞定位：

Host endoplasmic reticulum membrane; Multi-pass membrane protein. Host Golgi apparatus, host cis-Golgi network membrane; Multi-pass membrane protein.
蛋白家族：

HTLV-1 accessory protein p12I family