Recombinant Human SARS coronavirus Membrane protein (M)

in vitro E.coli expression system

中文名稱：

Recombinant Human SARS coronavirus Membrane protein(M)
貨號：

CSB-CF348664HQE
說明書：

MSDS Datasheet
規格：
來源：

in vitro E.coli expression system
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

基因名：

M
Uniprot No.：

P59596
別名：

M; 5; Membrane protein; M protein; E1 glycoprotein; Matrix glycoprotein; Membrane glycoprotein
種屬：

Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus)
蛋白長度：

full length protein
表達區域：

1-221
氨基酸序列

MADNGTITVEELKQLLEQWNLVIGFLFLAWIMLLQFAYSNRNRFLYIIKLVFLWLLWPVT LACFVLAAVYRINWVTGGIAIAMACIVGLMWLSYFVASFRLFARTRSMWSFNPETNILLN VPLRGTIVTRPLMESELVIGAVIIRGHLRMAGHSLGRCDIKDLPKEITVATSRTLSYYKL GASQRVGTDSGFAAYNRYRIGNYKLNTDHAGSNDNIALLVQ
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.
基因功能參考文獻：
1. Specific amino acids are critical for M protein function in terms of directing virus assembly. PMID: 23700447
2. Like S, M acquires high-mannose N-glycans that are subsequently modified into complex N-glycans in the Golgi. PMID: 15831954
3. This is the first report describing the induction of apoptosis by SARS-CoV M protein in animal cells and possible implications are discussed. PMID: 16797548
4. The results show that M and N proteins of SARS-CoV can induce apoptosis of human pulmonary fibroblast cells. PMID: 16845612
5. The crystal structure of M(pro) at a resolution of 1.82 Angstroms, in space group P2(1) at pH 6.0, is reported. PMID: 17196984
6. cytoplasmic C-terminus domain of SARS-CoV M protein was responsible for binding to NC protein PMID: 18792806
7. the expression of M protein prevents the formation of TRAF3.TANK.TBK1/IKKepsilon complex and thereby inhibits TBK1/IKKepsilon-dependent activation of IRF3/IRF7 transcription factors PMID: 19380580
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亞細胞定位：

Virion membrane; Multi-pass membrane protein. Host Golgi apparatus membrane; Multi-pass membrane protein.
蛋白家族：

Betacoronaviruses M protein family
數據庫鏈接：

KEGG: vg:1489672