Recombinant Human Polymeric immunoglobulin receptor (PIGR)

in vitro E.coli expression system

中文名稱：

人PIGR重組蛋白
貨號：

CSB-CF017981HU
說明書：

MSDS Datasheet
規格：
來源：

in vitro E.coli expression system
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

基因名：

PIGR
Uniprot No.：

P01833
別名：

PIGR; Polymeric immunoglobulin receptor; PIgR; Poly-Ig receptor; Hepatocellular carcinoma-associated protein TB6
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length of Mature Protein
表達區域：

19-764
氨基酸序列

KSPIFGPEEVNSVEGNSVSITCYYPPTSVNRHTRKYWCRQGARGGCITLISSEGYVSSKYAGRANLTNFPENGTFVVNIAQLSQDDSGRYKCGLGINSRGLSFDVSLEVSQGPGLLNDTKVYTVDLGRTVTINCPFKTENAQKRKSLYKQIGLYPVLVIDSSGYVNPNYTGRIRLDIQGTGQLLFSVVINQLRLSDAGQYLCQAGDDSNSNKKNADLQVLKPEPELVYEDLRGSVTFHCALGPEVANVAKFLCRQSSGENCDVVVNTLGKRAPAFEGRILLNPQDKDGSFSVVITGLRKEDAGRYLCGAHSDGQLQEGSPIQAWQLFVNEESTIPRSPTVVKGVAGGSVAVLCPYNRKESKSIKYWCLWEGAQNGRCPLLVDSEGWVKAQYEGRLSLLEEPGNGTFTVILNQLTSRDAGFYWCLTNGDTLWRTTVEIKIIEGEPNLKVPGNVTAVLGETLKVPCHFPCKFSSYEKYWCKWNNTGCQALPSQDEGPSKAFVNCDENSRLVSLTLNLVTRADEGWYWCGVKQGHFYGETAAVYVAVEERKAAGSRDVSLAKADAAPDEKVLDSGFREIENKAIQDPRLFAEEKAVADTRDQADGSRASVDSGSSEEQGGSSRALVSTLVPLGLVLAVGAVAVGVARARHRKNVDRVSIRSYRTDISMSDFENSREFGANDNMGASSITQETSLGGKEEFVATTESTTETKEPKKAKRSSKEEAEMAYKDFLLQSSTVAAEAQDGPQEA
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.; Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens. On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells.
基因功能參考文獻：
1. We identified two SLN genes (PIGR and TFAP2A) that provided high prognostic accuracy in SLN-positive melanoma patients (AUC = 0.864). These two SLN genes, along with clinicopathological features, can differentiate the high- and low-risk groups in node-positive melanoma patients. PMID: 27663566
2. pIgR may be involved in pancreatic ductal adenocarcinoma progression and may be linked stromal activity. Further work on its precise role is mandated in in vivo models, to understand its influence on cancer progression. PMID: 28173980
3. A genome-wide trans-ethnic interaction study links the PIGR-FCAMR locus to coronary atherosclerosis via interactions between genetic variants and residential exposure to traffic pollution. PMID: 28355232
4. The polymeric immunoglobulin receptor secretory component structure comprises five immunoglobulin-like domains (D1-D5) arranged as a triangle, with an interface between ligand-binding domains D1 and D5. PMID: 26943617
5. Reduced expression of the polymeric immunoglobulin receptor in pancreatic and periampullary adenocarcinoma signifies tumour progression and poor prognosis. PMID: 25397670
6. Crohn disease patients were characterized as having decreased median expression of PIGR, in non-inflamed colonic mucosa. By contrast, Ulcerative colitis patients exhibited decreased expression of PIGR in colon mucosa. PMID: 25956706
7. Report PIGR expression in human fallopian tubes, primary epithelial ovarian tumours and metastases. PMID: 24568264
8. the polymeric immunoglobulin receptor (pIgR) is highly expressed by renal cyst-lining cells. pIgR expression is, in part, driven by aberrant STAT6 pathway activation. PMID: 25922073
9. Positive expression of pIgR was statistically significantly associated with poor prognosis of patients with colon carcinoma hepatic metastasis. PMID: 26176052
10. In conclusion these data suggest that Streptococcus pneumoniae PspC-promoted uptake via the polymeric immunoglobulin receptor of epithelial cells is mediated by both clathrin and caveolin dependent pathway. PMID: 25455218
11. Polymeric immunoglobulin receptor expression is correlated with poor prognosis in patients with osteosarcoma. PMID: 24699841
12. High PIGR expression independently predicts a decreased risk of recurrence and an improved survival in patients with adenocarcinoma of the upper gastrointestinal tract PMID: 24694107
13. pIgR down-regulation in chronic obstructive pulmonary disease correlates with severity. Bronchial epithelium in vitro retains aberrant imprinting for pIgR expression. pIgR down-regulation is linked to TGF-beta-driven reprogramming of bronchial epithelium. PMID: 25078120
14. Results indicated that the polymeric immunoglobulin receptor (pIgR) can be divided into several functionally distinct regions. PMID: 23809084
15. Polymeric immunoglobulin receptor (PIGR)expression was lost in most lung cancers and pre-invasive bronchial lesions, suggesting that PIGR downregulation is an early event in lung tumourigenesis. PIGR overexpression inhibited cell proliferation. PMID: 21965228
16. The comparison of nonsmokers, smokers, and smokers with moderate COPD revealed 15 changed proteins with the majority, including polymeric immunoglobulin receptor (PIGR), being elevated in smokers and subjects with COPD. PMID: 22053820
17. Both native and phage-bound variable domain of camelid derived heavy chain only antibodies, were only able to get across polarized MDCK cells that express the human pIgR gene in a basolateral to apical fashion. PMID: 22022593
18. Results identify pIgR as a potential link between hepatitis B virus-derived hepatitis and HCC metastasis and provide evidence in support of pIgR as a prognostic biomarker for HCC and a potential therapeutic target. PMID: 22025622
19. Streptococcus pneumoniae infection of host epithelial cells via polymeric immunoglobulin receptor transiently induces calcium release from intracellular stores. PMID: 21454571
20. Data illustrate the importance of a coordinated signaling between Src PTKs, ERK1/2, and JNK during pIgR-mediated uptake of pneumococci by host epithelial cells. PMID: 20829350
21. characterization of the human pIgR promoter and the essential role that eight different nuclear complexes have in controlling basal expression of this gene in Caco-2 cells PMID: 12121890
22. cooperative binding of multiple transcription factors regulates basal activity of the human PIGR promoter PMID: 12165516
23. facilitates invasion of epithelial cells by Streptococcus pneumoniae in a strain-specific and cell type-specific manner PMID: 12183558
24. The carboxyl-terminal domains of IgA and IgM direct isotype-specific polymerization and interaction with this receptor PMID: 12213814
25. This protein is cleaved by neutrophil serine proteinases but its epithelial production is increased by neutrophils through NF-kappa B- and p38 mitogen-activated protein kinase-dependent mechanisms. PMID: 12654638
26. It seems that a gene associated with susceptibility to immunoglobulin A nephropathy lies within or close to the PIGR gene locus on chromosome 1q in the Japanese population. PMID: 12740691
27. there is a conformational CbpA-binding motif in the D3/D4 region of human polymeric immunoglobulin receptor, which is functionally separated from the IgA-binding site PMID: 13679368
28. transcription factors upstream stimulatory factor (USF) and c-Myc may exert opposing effects on PIGR promoter activity PMID: 14644095
29. Ectodomains 3 and 4 of human polymeric Immunoglobulin receptor have a role in mediating adherence and internalization of Streptococcus pneumoniae into epithelial cells PMID: 14660617
30. TNF-induced up-regulation of the human pIgR critically depends on an NF-kappa B site and flanking sequences within a 204-bp region of the first intron in the pIgR gene, a region largely overlapping with a recently characterized IL-4-responsive enhancer. PMID: 15265917
31. USF1 and USF2 mRNA levels were reduced in non-small cell lung carcinoma; AP2-alpha levels were elevated; regression analysis demonstrated that reduced USF2 mRNA & increased AP2-alpha mRNA levels were predictive of downregulated PIGR mRNA expression PMID: 15864740
32. TLR3 and TLR4 signal primarily through NF-kappaB to enhance transcription of pIgR mRNA. PMID: 15972671
33. This review expands our view of the immunobiology of pIgR, a key component of the mucosal immune system that bridges innate and adaptive immune defense. PMID: 16048543
34. interaction of dimeric IgA (dIgA) (the predominant form of IgA polymer) with the pIgR PMID: 16272325
35. Secretory component (SC) is derived from the polymeric immunoglobulin receptor (pIgR). The purified free form of SC binds IgM with a physiological equilibrium dissociation constant of 4.6x10(-8) M and shares structural similarity to native SC. PMID: 16288892
36. This work represents the first analysis of the three-dimensional structure of full-length free secretory component (SC) and paves the way to a better understanding of the association between SC and its potential ligands. PMID: 17428798
37. In cultured Caco-2 cells, tumor necrosis factor-alpha (TNF-alpha) dose-dependently increased polymeric immunoglobulin receptor (pIg) mRNA. PMID: 17460948
38. Fcalpha/muR had different tissue distribution patterns to pIgR in the intestine. PMID: 19338768
39. A novel NF-kappa B/Rel site in intron 1 cooperates with proximal promoter elements to mediate TNF-alpha-induced transcription of the human polymeric Ig receptor PMID: 11714807
40. IL-4 responsiveness mediated by an enhancer located in intron 1; both direct and indirect involvement of STAT6 PMID: 11034397
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亞細胞定位：

[Polymeric immunoglobulin receptor]: Cell membrane; Single-pass type I membrane protein.; [Secretory component]: Secreted.
數據庫鏈接：

HGNC: 8968

OMIM: 173880

KEGG: hsa:5284

STRING: 9606.ENSP00000348888

UniGene: Hs.497589