Recombinant Human Bladder cancer-associated protein (BLCAP)

in vitro E.coli expression system

中文名稱：

Recombinant Human Bladder cancer-associated protein(BLCAP)
貨號：

CSB-CF002712HU
規格：
來源：

in vitro E.coli expression system
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

基因名：

BLCAP
Uniprot No.：

P62952
別名：

BLCAP; BC10; Bladder cancer-associated protein; Bladder cancer 10 kDa protein; Bc10
種屬：

Homo sapiens (Human)
蛋白長度：

Full length protein
表達區域：

1-87
氨基酸序列

MYCLQWLLPVLLIPKPLNPALWFSHSMFMGFYLLSFLLERKPCTICALVFLAALFLICYS CWGNCFLYHCSDSPLPESAHDPGVVGT
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B.
基因功能參考文獻：
1. Upregulated miR-9-3p has a positive role in human MTC progression by regulating the growth and apoptosis of cancer cells via targeting BLCAP. PMID: 27938505
2. Our findings reveal that A-to-I RNA editing events alter the genetically coded amino acid in BLCAP YXXQ motif, which drive the progression of cervical carcinogenesis through regulating STAT3 signaling pathway. PMID: 28455960
3. data indicates that Blcap is a novel Stat3 interaction partner and suggests a role for Blcap in the Stat3-mediated progression of precancerous lesions to invasive tumors of the bladder PMID: 29190807
4. the functional association of BLCAP and Rb1 might play important roles in proliferation and apoptosis of HeLa cells. PMID: 26986503
5. Data show that the RNA-edited bladder cancer associated protein (BLCAP) gene may stably promote cell proliferation. PMID: 25499081
6. Immunoexpression analysis and prognostic value of BLCAP in breast cancer PMID: 23049907
7. observed a general decrease in BLCAP-editing level in astrocytomas, bladder cancer and colorectal cancer when compared with the related normal tissues PMID: 19908260
8. Data show that loss of BLCAP expression is associated with tumor progression. PMID: 19783793
9. might be a potential tumor suppressor gene in cervical carcinoma. PMID: 16675915
10. BLCAP may play a role not only in regulating cell proliferation but also in coordinating apoptosis and cell cycle via a novel way independent of p53 and NF-kappaB. PMID: 17031575
11. Blcap is imprinted in mouse and human brain, but not in other mouse tissues. PMID: 18836209
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亞細胞定位：

Membrane; Multi-pass membrane protein.
蛋白家族：

BLCAP family
組織特異性：

Ubiquitous. Expressed in cervical tissues. Down-regulated in bladder invasive carcinoma, renal cell carcinoma and in primary cervical carcinoma.
數據庫鏈接：

HGNC: 1055

OMIM: 613110

KEGG: hsa:10904

STRING: 9606.ENSP00000362637

UniGene: Hs.472651