Recombinant Emerin homolog 1 (emr-1)

in vitro E.coli expression system

中文名稱：

秀麗隱桿線蟲emr-1重組蛋白
貨號：

CSB-CF519041CXY
說明書：

MSDS Datasheet
規(guī)格：
來源：

in vitro E.coli expression system
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

基因名：

emr-1
Uniprot No.：

O01971
別名：

emr-1; M01D7.6; Emerin homolog 1; Ce-emerin
種屬：

Caenorhabditis elegans
蛋白長度：

full length protein
表達區(qū)域：

1-166
氨基酸序列

MDVSQLTDAELRDSLKSHGVSVGPIVATTRKLYEKKLIKLSDGSINNQSNLNDSQFNEDS LIISSSPKKSPPQRVFQNVSAATAAATTSPESDSDDCEESMRYLTEEEMAADRASARQAQ SNKGGFLGSTITFTILFVFIAVFAYFLIENAEQLKLVAETNPEDTI
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標(biāo)簽：

N-terminal 10xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Involved in chromosome segregation and cell division, probably via its interaction with lmn-1, the main component of nuclear lamina. Has some overlapping function with lem-2. May play a role in radiation-induced DNA damage repair response.
基因功能參考文獻：
1. We demonstrate a specific role of EMR-1 in neuromuscular junction activity that may contribute to Emery-Dreifuss muscular dystrophy in humans PMID: 24490688
2. these results clearly show that Ce-emerin and LEM-2 have additional roles in specific tissues, including striated muscle and smooth muscle. PMID: 22171324
3. LEM domain proteins are essential for cell division and that Ce-emerin and Ce-MAN1 share at least one and possibly multiple overlapping functions, which may be relevant to Emery-Dreifuss muscular dystrophy PMID: 12684533
亞細胞定位：

Nucleus envelope. Nucleus inner membrane; Single-pass membrane protein; Nucleoplasmic side.
組織特異性：

Ubiquitous. Expressed in all cells, except in cells undergoing spermatogenesis.
數(shù)據(jù)庫鏈接：

KEGG: cel:CELE_M01D7.6

STRING: 6239.M01D7.6.1

UniGene: Cel.18441