Recombinant Adenosine monophosphate-protein transferase FICD homolog (ZK593.8)

in vitro E.coli expression system

中文名稱：

秀麗隱桿線蟲fic-1重組蛋白
貨號：

CSB-CF638743CXY
說明書：

MSDS Datasheet
規格：
來源：

in vitro E.coli expression system
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

基因名：

fic-1
Uniprot No.：

Q23544
別名：

fic-1; ZK593.8; Protein adenylyltransferase fic-1; De-AMPylase fic-1
種屬：

Caenorhabditis elegans
蛋白長度：

full length protein
表達區域：

1-508
氨基酸序列

MSVRRRTHSDDFSYLLEKTRRPSKLNVVQEDPKSAPPQGYSLTTVIIISVLVSLICQHFV PYAVSTLHTVIKNSPKQKSSPPPSNRLNIGFISGNSPEKYAPAVQKPTFLVDPIYDEKWK GIQTAVPVMSTQTDEKRENDPAKVKEAILAAKAAGRSRKDGNLERAMTIMEHAMALAPTN PQILIEMGQIREMHNELVEADQCYVKALAYDPGNSEALVLRARTTPLVSAIDRKMLRSVH DLRDEFNHLQHSTALRRMMRETYFLYVYHTVAIEGNTLSLGQTRAILESGMVIPGKSIRE HNEVIGMDAALRFLNCSLLSKEHDEISIDDILEMHRRVLGNADPVEAGRIRTTQVYVGRF TPVSPEYVMEQLKDIVDWLNDESTLTIDPIERAAIAHYKLVLVHPFTDGNGRTARLLLNL IMMRSGFPPVILPVETRAEYYASLHVANLGDLRPFVRYVAKHSEASIQRYIGAMKTSSDN ILNSGDSKLTPEESEVSEKIEAECRAGN
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context. The side chain of Glu-274 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place. Adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins. In vivo target proteins include the heat-shock 70 family proteins hsp-1 and hsp-3 and the translation elongation factors eef-1A, eef-1G and eef-2. Can AMPylate core histone H3 in vitro. Can also act as a phosphodiesterase by mediating removal of ATP (de-AMPylation) from target proteins. Decreases susceptibility to P.aeruginosa-mediated killing and might therefore play a role in the innate immune response.
基因功能參考文獻：
1. We identify a link between FIC-1-mediated AMPylation and susceptibility to the pathogen Pseudomonas aeruginosa, establishing a connection between AMPylation and innate immunity in C. elegans PMID: 27138431
亞細胞定位：

Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein.
蛋白家族：

Fic family
組織特異性：

Ubiquitously expressed, with high expression in the germline.
數據庫鏈接：

KEGG: cel:CELE_ZK593.8

STRING: 6239.ZK593.8

UniGene: Cel.17773