Recombinant Xenopus laevis Mitogen-activated protein kinase 8 (mapk8)

中文名稱：

有爪蟾蜍mapk8重組蛋白
貨號：

CSB-YP013466XBE
規格：
來源：

Yeast
其他：

中文名稱：

有爪蟾蜍mapk8重組蛋白
貨號：

CSB-EP013466XBE
規格：
來源：

E.coli
其他：

中文名稱：

有爪蟾蜍mapk8重組蛋白
貨號：

CSB-EP013466XBE-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

有爪蟾蜍mapk8重組蛋白
貨號：

CSB-BP013466XBE
規格：
來源：

Baculovirus
其他：

中文名稱：

有爪蟾蜍mapk8重組蛋白
貨號：

CSB-MP013466XBE
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

mapk8
Uniprot No.：

Q8QHK8
別名：

mapk8; jnk1; Mitogen-activated protein kinase 8; MAP kinase 8; MAPK 8; EC 2.7.11.24; Stress-activated protein kinase JNK1
種屬：

Xenopus laevis (African clawed frog)
蛋白長度：

full length protein
表達區域：

1-426
氨基酸序列

MSRSKRDSNF SVFEIGDSTF TVLKRYQNLK PIGSGAQGIV CAAFDAVLER HVAIKKLSRP FQNQTHAKRA YRELVLMKCV NHKNIIGLLN VFTPQKSLEE FQDLYIVMEL MDANLCQVIQ MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTAGTSF MMTPYVVTRY YRAPEVILGM GYKENVDIWS VGCILGEMIK GGVLFPGTDH IDQWNKVIEQ LGTPCTEFMK KLQPTVRTYV ENRPKYAGYS FEKLFPDVLF PADSEHNKLK ASQARDLLSK MLVIDASKRI SVDDALQHPY INVWYDPLEA EAPPPKIPDK QLDEREHTIE EWKELIYKEV LDWEERAKNG VIRGQPAPLG AAVTDGSQAH TSSSSGDASS MSTDPTLPSD TDSSLETSAG TLGCCR
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulating transcriptional activity. Regulates morphogenic cell movements, controlling convergent extension during gastrulation. May play a role in the regulation of the circadian clock.
基因功能參考文獻：
1. The results of this study suggest that JNK has a role in the disassembly adherens junctions by means of endocytosis that is required during buccopharyngeal membrane perforation. PMID: 28032936
2. Hyperosmotic Shock Engages Two Positive Feedback Loops through Caspase-3-dependent Proteolysis of JNK1-2 and Bid. PMID: 26511318
3. JNK signaling is required to establish microtubule stability and maintain tissue cohesion in the gut. PMID: 23462475
4. Data show that the death pathway is independent of ERK but relies on activating Bad phosphorylation through the control of both kinases Cdk1 and JNK. PMID: 21858202
亞細胞定位：

Cytoplasm. Nucleus. Cell junction, synapse.
蛋白家族：

Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily
組織特異性：

Strongly expressed in presumptive ectoderm and mesoderm regions and weakly expressed in endoderm regions during early stages of embryo development. Expressed in the head and dorsal regions during neurula and tailbud stages.
數據庫鏈接：

KEGG: xla:379876

UniGene: Xl.8740