Recombinant Xenopus laevis Frizzled-8 (fzd8), partial

中文名稱：

有爪蟾蜍fzd8重組蛋白
貨號：

CSB-YP009111XBE1
規格：
來源：

Yeast
其他：

中文名稱：

有爪蟾蜍fzd8重組蛋白
貨號：

CSB-EP009111XBE1
規格：
來源：

E.coli
其他：

中文名稱：

有爪蟾蜍fzd8重組蛋白
貨號：

CSB-EP009111XBE1-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

有爪蟾蜍fzd8重組蛋白
貨號：

CSB-BP009111XBE1
規格：
來源：

Baculovirus
其他：

中文名稱：

有爪蟾蜍fzd8重組蛋白
貨號：

CSB-MP009111XBE1
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

fzd8
Uniprot No.：

O93274
別名：

fzd8; fz8; Frizzled-8; Fz-8; Xfz8
種屬：

Xenopus laevis (African clawed frog)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activation by Wnt8, Wnt5A or Wnt3A induces expression of beta-catenin target genes. Displays an axis-inducing activity.
基因功能參考文獻：
1. Data suggest that Sizzled is unlikely able to antagonize Wnt signaling; however, structure of Sizzled provides a framework for understanding full-length structure of secreted Frizzled-related proteins such as frizzled-8 and their interaction with and antagonism of Wnt proteins such as Wnt-8. PMID: 28808056
亞細胞定位：

Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor Fz/Smo family
數據庫鏈接：

KEGG: xla:373690

UniGene: Xl.293