Recombinant Xenopus laevis Aurora kinase B-A (aurkb-a)

中文名稱：

Recombinant Xenopus laevis Aurora kinase B-A(aurkb-a)
貨號：

CSB-YP724906XBE
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Xenopus laevis Aurora kinase B-A(aurkb-a)
貨號：

CSB-EP724906XBE
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Xenopus laevis Aurora kinase B-A(aurkb-a)
貨號：

CSB-EP724906XBE-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Xenopus laevis Aurora kinase B-A(aurkb-a)
貨號：

CSB-BP724906XBE
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Xenopus laevis Aurora kinase B-A(aurkb-a)
貨號：

CSB-MP724906XBE
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

aurkb-a
Uniprot No.：

Q6DE08
別名：

aurkb-a; airk2-aAurora kinase B-A; EC 2.7.11.1; Aurora/IPL1-related kinase 2-A; AIRK2-A; XAIRK2-A; Serine/threonine-protein kinase 12-A; Serine/threonine-protein kinase aurora-B-A; xAurora-B
種屬：

Xenopus laevis (African clawed frog)
蛋白長度：

full length protein
表達區域：

1-361
氨基酸序列

MSYKENLNPS SYTSKFTTPS SATAAQRVLR KEPYVSTFTT PSDNLLAQRT QLSRITPSAS SSVPGRVAVS TEMPSQNTAL AEMPKRKFTI DDFDIGRPLG KGKFGNVYLA REKQNKFIMA LKVLFKSQLE KEGVEHQLRR EIEIQSHLRH PNILRMYNYF HDRKRIYLML EFAPRGELYK ELQKHGRFDE QRSATFMEEL ADALHYCHER KVIHRDIKPE NLLMGYKGEL KIADFGWSVH APSLRRRTMC GTLDYLPPEM IEGKTHDEKV DLWCAGVLCY EFLVGMPPFD SPSHTETHRR IVNVDLKFPP FLSDGSKDLI SKLLRYHPPQ RLPLKGVMEH PWVKANSRRV LPPVYQSTQS K
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Phosphorylates 'Ser-10' of histone H3 during mitosis.
基因功能參考文獻：
1. AurB as an important RNA-dependent spindle assembly factor PMID: 24968351
2. Data suggest a model in which microtubules act as scaffolds for the enzymatic activity of Aurora-B. PMID: 24498282
3. ICIS and Aurora B coregulate the microtubule depolymerase Kif2a. PMID: 19327998
4. results suggest an essential combined function of AurA and AurB in chromosome segregation and anaphase MT dynamics PMID: 22184196
5. Aurora B pathway is suppressed in the cytoplasm of Xenopus egg extract by phosphatases, but that it becomes activated by chromatin via a Ran-independent mechanism. PMID: 17199039
6. Aurora kinase B controls spindle bipolarity via inhibition of endogenous MCAK. PMID: 22751439
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亞細胞定位：

Nucleus. Chromosome. Note=Chromosomal until metaphase but transfers to the midzone microtubule array and the equatorial cortex during anaphase.
蛋白家族：

Protein kinase superfamily, Ser/Thr protein kinase family, Aurora subfamily
數據庫鏈接：

KEGG: xla:398457

UniGene: Xl.6652