Recombinant Varicella-zoster virus Serine/threonine-protein kinase US3 homolog (66)

中文名稱：

Recombinant Varicella-zoster virus Serine/threonine-protein kinase US3 homolog(66)
貨號：

CSB-YP362626VAP
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Varicella-zoster virus Serine/threonine-protein kinase US3 homolog(66)
貨號：

CSB-EP362626VAP
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Varicella-zoster virus Serine/threonine-protein kinase US3 homolog(66)
貨號：

CSB-EP362626VAP-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Varicella-zoster virus Serine/threonine-protein kinase US3 homolog(66)
貨號：

CSB-BP362626VAP
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Varicella-zoster virus Serine/threonine-protein kinase US3 homolog(66)
貨號：

CSB-MP362626VAP
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

66
Uniprot No.：

P09251
別名：

66; Serine/threonine-protein kinase US3 homolog; Protein kinase ORF66; EC 2.7.11.1
種屬：

Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3)
蛋白長度：

full length protein
表達區域：

1-393
氨基酸序列

MNDVDATDTFVGQGKFRGAISTSPSHIMQTCGFIQQMFPVEMSPGIESEDDPNYDVNMDI QSFNIFDGVHETEAEASVALCAEARVGINKAGFVILKTFTPGAEGFAFACMDSKTCEHVV IKAGQRQGTATEATVLRALTHPSVVQLKGTFTYNKMTCLILPRYRTDLYCYLAAKRNLPI CDILAIQRSVLRALQYLHNNSIIHRDIKSENIFINHPGDVCVGDFGAACFPVDINANRYY GWAGTIATNSPELLARDPYGPAVDIWSAGIVLFEMATGQNSLFERDGLDGNCDSERQIKL IIRRSGTHPNEFPINPTSNLRRQYIGLAKRSSRKPGSRPLWTNLYELPIDLEYLICKMLS FDARHRPSAEVLLNHSVFQTLPDPYPNPMEVGD
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Multifunctional serine/threonine kinase that plays a role in several processes including egress of virus particles from the nucleus, modulation of the actin cytoskeleton and inhibition of apoptosis. Phosphorylates proteins 24 and 27, two critical regulators of capsid budding from nucleus to endoplasmic reticulum, thereby facilitating virion egress. Modulates and redistributes host components of the nuclear envelope, including LMNA, emerin/EMD and the nuclear matrix protein MATR3. Phosphorylates envelope glycoprotein B (gB), probably to direct it to the cell surface. Promotes virus intracellular spread by restructuring host cell cytoskeleton. Blocks host apoptosis to extend cell survival and allow efficient viral replication. Promotes viral gene expression by phosphorylating host HDAC2 to reduce viral genome silencing. Downregulates class I major histocompatibility complex (MHC-I) surface expression. Additionally, phosphorylates IE62 and targets it to the cytoplasm. The nuclear exclusion of IE62 enables the packaging of abundant levels of IE62 into virions.
基因功能參考文獻：
1. These studies reveal that host cell-derived Sp1 and TBP and viral IE62 and IE63 factors contribute to and cooperate in the expression of this important viral kinase gene. PMID: 21074584
2. The Varicella-Zoster Virus ORFkinase has important cell-type-specific functions that are separate from those affecting IE62 and apoptosis. PMID: 18495764
亞細胞定位：

Host cytoplasm. Host nucleus.
蛋白家族：

Protein kinase superfamily, Ser/Thr protein kinase family
數據庫鏈接：

KEGG: vg:1487703