Recombinant Staphylococcus aureus Immunoglobulin G-binding protein A (spa)

中文名稱：

金黃色釀膿葡萄球菌spa重組蛋白
貨號：

CSB-YP360925FLF
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

金黃色釀膿葡萄球菌spa重組蛋白
貨號：

CSB-EP360925FLF
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

金黃色釀膿葡萄球菌spa重組蛋白
貨號：

CSB-EP360925FLF-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

金黃色釀膿葡萄球菌spa重組蛋白
貨號：

CSB-BP360925FLF
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

金黃色釀膿葡萄球菌spa重組蛋白
貨號：

CSB-MP360925FLF
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

spa
Uniprot No.：

P02976
別名：

spa; SAOUHSC_00069; Immunoglobulin G-binding protein A; IgG-binding protein A; Staphylococcal protein A; SpA
種屬：

Staphylococcus aureus (strain NCTC 8325)
蛋白長度：

Full Length of Mature Protein
表達區域：

37-485
氨基酸序列

AQHD EAQQNAFYQV LNMPNLNADQ RNGFIQSLKD DPSQSANVLG EAQKLNDSQA PKADAQQNNF NKDQQSAFYE ILNMPNLNEA QRNGFIQSLK DDPSQSTNVL GEAKKLNESQ APKADNNFNK EQQNAFYEIL NMPNLNEEQR NGFIQSLKDD PSQSANLLSE AKKLNESQAP KADNKFNKEQ QNAFYEILHL PNLNEEQRNG FIQSLKDDPS QSANLLAEAK KLNDAQAPKA DNKFNKEQQN AFYEILHLPN LTEEQRNGFI QSLKDDPSVS KEILAEAKKL NDAQAPKEED NNKPGKEDNN KPGKEDNNKP GKEDNNKPGK EDNNKPGKED GNKPGKEDNK KPGKEDGNKP GKEDNKKPGK EDGNKPGKED GNKPGKEDGN GVHVVKPGDT VNDIAKANGT TADKIAADNK LADKNMIKPG QELVVDKKQP ANHADANKAQ ALPET
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Plays a role in the inhibition of the host innate and adaptive immune responses. Possesses five immunoglobulin-binding domains that capture both the fragment crystallizable region (Fc region) and the Fab region (part of Ig that identifies antigen) of immunoglobulins. In turn, Staphylococcus aureus is protected from phagocytic killing via inhibition of Ig Fc region. In addition, the host elicited B-cell response is prevented due to a decrease of antibody-secreting cell proliferation that enter the bone marrow, thereby decreasing long-term antibody production. Inhibits osteogenesis by preventing osteoblast proliferation and expression of alkaline phosphatase, type I collagen, osteopontin and osteocalcin. Acts directly as a proinflammatory factor in the lung through its ability to bind and activate tumor necrosis factor alpha receptor 1/TNFRSF1A.
基因功能參考文獻：
1. The co-operativity of ultra-fast folding of protein A and whether the Phi-value analysis of its transition state depended on the location of the optical probe, was determined. PMID: 16782128
2. Clumping factor and protein A-negative methicillin resistant S. aureus isolated in Poland do not come from a single clone and the absence of CF and protein A is not caused by the deletion of other genes. PMID: 17011150
3. Staphylococcus aureus protein A activates TACE through EGFR-dependent signaling. PMID: 17255933
4. A two-state folding mechanism of protein A supports the existence of effective nonlocal, probably hydrophobic, intramolecular interactions that stabilize a uniform ensemble of compact denatured molecules at intermediate denaturing conditions. PMID: 19222162
亞細胞定位：

Secreted, cell wall; Peptidoglycan-anchor; Extracellular side. Secreted.
數據庫鏈接：

KEGG: sao:SAOUHSC_00069

STRING: 93061.SAOUHSC_00069