Recombinant Rat Tubulin alpha-1A chain (Tuba1a)

中文名稱：

大鼠Tuba1a重組蛋白
貨號：

CSB-YP025306RA
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Tuba1a重組蛋白
貨號：

CSB-EP025306RA
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Tuba1a重組蛋白
貨號：

CSB-EP025306RA-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Tuba1a重組蛋白
貨號：

CSB-BP025306RA
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Tuba1a重組蛋白
貨號：

CSB-MP025306RA
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Tuba1a
Uniprot No.：

P68370
別名：

Tuba1a; Tuba1; Tubulin alpha-1A chain; Alpha-tubulin 1; Tubulin alpha-1 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain]
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full length protein
表達區域：

1-451
氨基酸序列

MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK HVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLD RIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTA VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITA SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN QMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPP TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE AREDMAALEKDYEEVGVDSVEGEGEEEGEEY
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
基因功能參考文獻：
1. These results agree with the hypothesis that the acetylation of alpha-tubulin by ATAT1 regulates the intracellular transport of secretory granules in corticotrophs. PMID: 27314403
2. Tubulin tail sequences and post-translational modifications regulate closure of mitochondrial voltage-dependent anion channel, VDAC. PMID: 26306046
3. TTL has specifically evolved to recognize and modify tubulin. PMID: 23358242
4. This finding reveals the importance of MEC-17 and alpha-tubulin acetylation in cortical development. PMID: 22972992
5. VDAC phosphorylation is an important determinant of its interaction with dimeric tubulin. PMID: 22022409
6. These results show that acetylation of alpha-tubulin is modulated in an activity-dependent manner in the rat hippocampus. PMID: 21400108
7. Alpha2B-adrenergic receptor interaction with tubulin controls its transport from the endoplasmic reticulum to the cell surface PMID: 21357695
8. Sarin causes altered time course of mRNA expression in the central nervous system of rats PMID: 11958514
9. cysteine reactivity of tubulin PMID: 12023292
10. cardiac tubulin is post-translationally modified during chronic heart failur in the rat PMID: 12236585
11. The binding of the antimitotic macrolide cryptophycin to tubulin induces two points of conformational curvature per heterodimer, the second site involving long-range changes that affect the alpha-subunit of tubulin. PMID: 12379108
12. data demonstrate an evolutionarily conserved property of ENTH domains to interact with tubulin and microtubules PMID: 12750376
13. In conclusion, our results indicate that beta-tubulin is critically controlled by TRbeta in the liver and that both TRs are probably needed to maintain the microtubular network organization of the liver. PMID: 15713690
14. Bcl-2, Bid, and Bad inhibit assembly sub-stoichiometrically, whereas peptides from Bak and Bax promote tubulin polymerization at near stoichiometric concentrations PMID: 16446153
15. the C-terminus of alpha-tubulin and its detyrosination are functionally important as a molecular switch that regulates cell cycle progression in vascular smooth muscle cells PMID: 17118269
16. Consistently, inhibition of tubulin tyrosination in rat hippocampal neurons resulted in the distribution of truncated kinesin-1 in both axons and dendrites. PMID: 19377471
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亞細胞定位：

Cytoplasm, cytoskeleton.
蛋白家族：

Tubulin family
數據庫鏈接：

KEGG: rno:64158

STRING: 10116.ENSRNOP00000006322

UniGene: Rn.234326