Recombinant Rat Speedy protein A (Spdya)

中文名稱：

大鼠Spdya重組蛋白
貨號：

CSB-YP837145RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

大鼠Spdya重組蛋白
貨號：

CSB-EP837145RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

大鼠Spdya重組蛋白
貨號：

CSB-EP837145RA-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Spdya重組蛋白
貨號：

CSB-BP837145RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Spdya重組蛋白
貨號：

CSB-MP837145RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Spdya
Uniprot No.：

Q8R496
別名：

Spdya; Spdy1; Speedy protein A; GS4; Rapid inducer of G2/M progression in oocytes A; RINGO A; Speedy-1; Spy1
種屬：

Rattus norvegicus (Rat)
蛋白長度：

full length protein
表達(dá)區(qū)域：

1-312
氨基酸序列

MRHNQMCCET PPTVTVHVKS GSNRSHQTRK PVSLKRPILK DSWQASEKNA HNNKPKRPRG PCLIIQRQEM TAFFKLFDDD LIQDFLWMDC CCKIADKYLL AMTFVYFKRA KFTISEHTRI NFFIALYLAN TVEEDEEEAK YEIFPWALGK NWRKLFPNFL KLRDQLWDRI DYRAIVSRRC CEEVMAIAPS HYIWQRERSV HHSGAARNYN RDEVHLPRGP SATPVDCSLC GKKGRYVRLG LSSSSSSSSD IVELTGKRSQ ELHNSLSMDM IGDPSQANTY SQVANDHQSK KENETNFVKK TKSMGWFAES EE
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

功能：

Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2. Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing a conformation change of the CDK2 T-loop that obstructs the substrate-binding cleft prior to kinase activation. Interferes with CDKN1B-mediated inhibition of CDK2. Mediates cell survival during the DNA damage process through activation of CDK2.
基因功能參考文獻(xiàn)：
1. LM23 played a protective role in H2O2-induced apoptosis of 293T cells, mediated at least in part through the Akt/PI3K signal pathway; these results provide new insights into the role of LM23 in the development of the testes and spermatogenesis. PMID: 23685908
2. Spy1 participated in the pathological process response to sciatic nerve injury and may be associated with Schwann cells proliferation and axons regeneration. PMID: 23129232
3. In the hippocampus, SpeedyRINGO acts as a savior for neurons that are under apoptosis. PMID: 22751172
4. Peripheral nerve injury induced an up-regulation of Spy1 in lumbar spinal cord, which was associated with glial proliferation. PMID: 19082704
5. testis-specific gene LM23 identified & characterized from rat type A spermatogonia, pachytene spermatocytes, & round spermatids. PMID: 17376406
6. LM23 is essential for spermatogenesis in Rattus norvegicus. PMID: 20036869
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亞細(xì)胞定位：

Nucleus.
蛋白家族：

Speedy/Ringo family
數(shù)據(jù)庫鏈接：

KEGG: rno:192209

STRING: 10116.ENSRNOP00000006073

UniGene: Rn.19576