Recombinant Rat Secretogranin-2 (Scg2)

中文名稱：

大鼠Scg2重組蛋白
貨號：

CSB-YP020808RA
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Scg2重組蛋白
貨號：

CSB-EP020808RA
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Scg2重組蛋白
貨號：

CSB-EP020808RA-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Scg2重組蛋白
貨號：

CSB-BP020808RA
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Scg2重組蛋白
貨號：

CSB-MP020808RA
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Scg2
Uniprot No.：

P10362
別名：

Scg2; Chgc; Scg-2; Secretogranin-2; Chromogranin-C; Secretogranin II; SgII) [Cleaved into: Secretoneurin; SN); Manserin]
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full length protein
表達區域：

31-619
氨基酸序列

QRNQLLQKEP DLRLENVQKF PSPEMIRALE YIEKLRQQAH REESSPDYNP YQGISVPLQL KENGEESHLA ESSRDVLSED EWMRIILEAL RQAENEPPSA LKENKPYALN LEKNFPVDTP DDYETQQWPE RKLKHMRFPL MYEENSRENP FKRTNEIVEE QYTPQSLATL ESVFQELGKL TGPSNQKRER VDEEQKLYTD DEDDVYKTNN IAYEDVVGGE DWSPMEEKIE TQTQEEVRDS KENTEKNEQI NEEMKRSGHL GLPDEGNRKE SKDQLSEDAS KVITYLRRLV NAVGSGRSQS GQNGDRAARL LERPLDSQSI YQLIEISRNL QIPPEDLIEM LKAGEKPNGL VEPEQDLELA VDLDDIPEAD IDRPDMFQSK TLSKGGYPKA PGRGMMEALP DGLSVEDILN VLGMENVANQ KSPYFPNQYS RDKALLRLPY GPGKSRANQI PKVAWIPDVE SRQAPYDNLN DKDQELGEYL ARMLVKYPEL MNTNQLKRVP SPGSSEDDLQ EEEQLEQAIK EHLGQGSSQE MEKLAKVSKR IPAGSLKNED TPNRQYLDED MLLKVLEYLN QEQAEQGREH LAKRAMENM
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules.
基因功能參考文獻：
1. EM66 (peptide derived from SCG2) gene expression is modulated by a negative energy status and suggest interactions between EM66 and NPY to regulate food intake through the POMC system. PMID: 28902709
2. Manserin localizes to secretory cells in the oviduct and may be involved in stress-induced gynecological disorders. PMID: 24360019
3. Manserin localizes to rat thyroid follicular epithelial cells and also to some parafollicular cells PMID: 22682498
4. The secretogranin II fragment secretoneurin reduces ischemia/reperfusion injury in the isolated perfused rat heart. PMID: 22655045
5. results indicate that manserin, occurring in the endocrine pancreas, may have a potential role in the endocrine system PMID: 20495819
6. SgII is a critical factor for the regulation of DCG biogenesis in neuroendocrine cells PMID: 20061385
7. GnRH-induced activation of the rat SgII promoter in the alphaT3-1 cell line requires cAMP-dependent protein kinase activity and a functional CRE within the 5'-flanking region of the gene PMID: 12581877
8. PCP[phencyclidine] modulates secretogranin II[sg II] expression in prefrontal cortex tissue in the absence of afferent inputs and that the nature of these changes is dependent upon the duration of exposure to and/or withdrawal from PCP PMID: 12969248
9. A novel 40 amino acid neuropeptide designated manserin (residues 529-568 of secretogranin II) localizes to endocrine cells of the pituitary anterior lobe and is observed in neuronal cells of hypothalamic nuclei and neurons in the median eminence. PMID: 15257142
10. MAPK signaling and ATF3 action are essential for full SgII promoter activation by GnRHa through a canonical CRE PMID: 17962349
11. analysis of the N- and C-terminal alpha-helical domains in secretogranin II PMID: 18299326
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亞細胞定位：

Secreted. Note=Neuroendocrine and endocrine secretory granules.
蛋白家族：

Chromogranin/secretogranin protein family
組織特異性：

[Manserin]: Brain. Expression in the pituitary is restricted to the anterior lobe. Expression in the hypothalamus is observed in the neuronal cells and neurons of arcuate nucleus, supraoptic nucleus and median eminence (at protein level).
數據庫鏈接：

KEGG: rno:24765

STRING: 10116.ENSRNOP00000020219

UniGene: Rn.230442