Recombinant Rat Secretogranin-1 (Chgb)

中文名稱：

Recombinant Rat Secretogranin-1(Chgb)
貨號：

CSB-YP005345RA
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Rat Secretogranin-1(Chgb)
貨號：

CSB-EP005345RA
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Rat Secretogranin-1(Chgb)
貨號：

CSB-EP005345RA-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Rat Secretogranin-1(Chgb)
貨號：

CSB-BP005345RA
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Rat Secretogranin-1(Chgb)
貨號：

CSB-MP005345RA
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Chgb
Uniprot No.：

O35314
別名：

Chgb; Secretogranin-1; Chromogranin-B; CgB; Glucagonoma peptide; Secretogranin-I; SgI) [Cleaved into: PE-11; CCB peptide short form; CCB peptide long form]
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full length protein
表達區域：

21-675
氨基酸序列

APVDNRDHNE EMVTRCIIEV LSNALSKSSA PTITPECRQV LRKSGKEVKG EEKGENENSK FEVRLLRDPS DASVGRWASS REETGAPVED SPGQAKVDNE EWTGGGGHSR EAVDDQESLH PSNQQVSKEA KIRHSEERGG KEEEEEEGKI YPKGEHRGDA GEEKKHTEES GEKHNAFSNK RSEASAKKKE ESVARAEAHF VELEKTHSRE QSSQESGEET RRQEKPQELP DQDQSEEESE EGEEGEEGAT SEVTKRRPRH HHWRSQSNKP SYEGRRPLSE ERKHAAGESK DANVATANLG EKRGHHLAHY RASEEEPDYG EELRSYPGFQ APQGLQYQGR GSEEVRAPSP RSEESQEKEY KRNHPDSELE STANRHSEET EEERSYEGAK GRQHRGRGRE PGAYPALDSR QEKRLLDEGH DPVHESPVDT AKRYPQSKWQ EQEKNYLNYD EEGDQGRWWQ QEEQLEPEES REEVSFPDRQ YAPYPTTEKR KRLGALFNPY FDPLQWKNSD FEKKGNPDDS FLDDDGEDGN GVTMTEKNFF PEYNYDWWEK RPFSEDVNWG YEKRSFARAP HLDLKRQYDD GVAELDQLLH YRKKAAEFPD FYDSEEQMGP HQEAEDEKDR ADQRVLTEEE KKELENLAAM DLELQKIAEK FSQRG
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.
基因功能參考文獻：
1. Possible involvement of Stat3 and Prlh1/Chgb up-regulation in the transition from short to repeated stress activation. PMID: 25217033
2. When released extra-cellulary, CHGB proteolytic fragments exert a feedback effect to inhibit catecholamine secretion. PMID: 24266713
3. Chrombacin is a 60 residue anti-microbial neuroendocrine peptide that includes an unusual sulfotyrosine-, phosphoserine-containing motif. PMID: 18181560
4. CGB was localized in the nucleus; transcription control role of CGB in the nucleus PMID: 11854265
5. Chromogranin B has a role in secretory granule biogenesis PMID: 12902350
6. CGB is a novel regulator of cardiomyocyte InsP(3)/Ca(2+)-dependent signaling, nuclear factor kappaB activity, and brain natriuretic peptide production PMID: 18420944
7. Stimulation with a secretagogue mixture induced parallel release of insulin and chromogranin B from pancreatic beta cells. PMID: 18437352
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亞細胞定位：

Secreted.
蛋白家族：

Chromogranin/secretogranin protein family
組織特異性：

Expressed in the brain, adrenal medulla and anterior pituitary. In the brain, localized to the hippocampal formation, the endocrine hypothalamus, the olfactory system, and in anatomically distinct structures in the pons-medulla.
數據庫鏈接：

KEGG: rno:24259

STRING: 10116.ENSRNOP00000028892

UniGene: Rn.11090