Recombinant Rat Protein-arginine deiminase type-4 (Padi4)

中文名稱：

大鼠Padi4重組蛋白
貨號：

CSB-YP017379RA
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Padi4重組蛋白
貨號：

CSB-EP017379RA
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Padi4重組蛋白
貨號：

CSB-EP017379RA-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Padi4重組蛋白
貨號：

CSB-BP017379RA
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Padi4重組蛋白
貨號：

CSB-MP017379RA
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Padi4
Uniprot No.：

O88807
別名：

Padi4; Pad4; Pdi4Protein-arginine deiminase type-4; EC 3.5.3.15; PAD-R4; Peptidylarginine deiminase IV; Peptidylarginine deiminase type alpha; Protein-arginine deiminase type IV
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full length protein
表達區域：

1-666
氨基酸序列

MAQGAVIHVA PEEPTHAVCV VGTATPLDIR GSAPRGSTSF SITASPEVVV DVIHGPPSKK STTGASKWPL DPKLEVTLQM KAASSRIDDQ KVRISYYGPK TSSTQALLYL TGVELSLSAD VTRTGKAKPA PAGKDQSTWT WGPDGHGAIL LVNCDKEDPK SSGMDFEDDK VLDNKDLQDM SPMTLSTKTP KDFFDKYQLV LQVPKAKMNK VRVFRATRGK LPSRYKVVLG PQQFSHRLEL LGGQHSTDFY VEGLAFPDAD FKGLIPLTIS LLDKSNPELP EALVFQDTVM FRVAPWIMTP NTQPPQEVYV CRFSDNEDFL KSLATFTKKA KCKLTVCPEE ENQDDQWMQD EMEIGYIQAP HKTLPVVFDS PRDRGLKDFP VKRVMGPNFG YVTRGLYRAE VTGLDAFGNL EVSPPVTVRG KEYPLGRILI GSSGYSSSES RDMHQILQDF LGAQQVQAPV RLFSDWLFVG HVDEFLSFVP ARGKQGFRLL LSSPRACYQM FQELQTEGHG EASLFEGLKR KRQTISDILS SQKLRDQNAY VESCIDWNRE VLKRELGLTE GDIIDIPQLF RIVGNSRGNP KAEAFFPNMV NMLVLGKHLG IPKPFGPIIN GRCCLEEKVC SLLEPLGLHC TFINDFYSYH MYHGEVHCGT NVRRKPFAFK WWHMVP
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci. Required for the formation of neutrophil extracellular traps (NETs); NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation. Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1.
亞細胞定位：

Cytoplasm. Nucleus. Cytoplasmic granule.
蛋白家族：

Protein arginine deiminase family
組織特異性：

Epidermis.
數據庫鏈接：

KEGG: rno:29512

STRING: 10116.ENSRNOP00000009081

UniGene: Rn.11155