Recombinant Rat Multidrug resistance-associated protein 5 (Abcc5), partial

中文名稱：

Recombinant Rat Multidrug resistance-associated protein 5(Abcc5) ,partial
貨號：

CSB-YP886186RA
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Rat Multidrug resistance-associated protein 5(Abcc5) ,partial
貨號：

CSB-EP886186RA
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Rat Multidrug resistance-associated protein 5(Abcc5) ,partial
貨號：

CSB-EP886186RA-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Rat Multidrug resistance-associated protein 5(Abcc5) ,partial
貨號：

CSB-BP886186RA
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Rat Multidrug resistance-associated protein 5(Abcc5) ,partial
貨號：

CSB-MP886186RA
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Abcc5
Uniprot No.：

Q9QYM0
別名：

Abcc5; Abcc5a; Mrp5; Multidrug resistance-associated protein 5; ATP-binding cassette sub-family C member 5
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of endogenous metabolites such as cAMP and cGMP, folic acid and N-lactoyl-amino acids (in vitro). Acts also as a general glutamate conjugate and analog transporter that can limit the brain levels of endogenous metabolites, drugs, and toxins. Confers resistance to the antiviral agent PMEA. Able to transport several anticancer drugs including methotrexate, and nucleotide analogs in vitro, however it does with low affinity, thus the exact role of ABCC5 in mediating resistance still needs to be elucidated. Acts as a heme transporter required for the translocation of cytosolic heme to the secretory pathway. May play a role in energy metabolism by regulating the glucagon-like peptide 1 (GLP-1) secretion from enteroendocrine cells.
基因功能參考文獻：
1. important role for MRP5-mediated cGMP efflux in the regulation of NO-induced cerebral arteriolar relaxation PMID: 14715514
2. cyclic nucleotide cellular efflux plays a critical role in elimination of intracellular cGMP but not cAMP in pituitary cells and such selectivity is achieved by expression of MRP5 PMID: 16614078
亞細胞定位：

Basolateral cell membrane; Multi-pass membrane protein. Golgi apparatus lumen. Endosome membrane. Cytoplasmic granule. Apical cell membrane; Multi-pass membrane protein.
蛋白家族：

ABC transporter superfamily, ABCC family, Conjugate transporter (TC 3.A.1.208) subfamily
數據庫鏈接：

KEGG: rno:116721

STRING: 10116.ENSRNOP00000002316

UniGene: Rn.9491