Recombinant Rat Meprin A subunit beta (Mep1b), partial

中文名稱：

大鼠Mep1b重組蛋白
貨號(hào)：

CSB-YP013702RA1
規(guī)格：
來(lái)源：

Yeast
其他：

中文名稱：

大鼠Mep1b重組蛋白
貨號(hào)：

CSB-EP013702RA1
規(guī)格：
來(lái)源：

E.coli
其他：

中文名稱：

大鼠Mep1b重組蛋白
貨號(hào)：

CSB-EP013702RA1-B
規(guī)格：
來(lái)源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Mep1b重組蛋白
貨號(hào)：

CSB-BP013702RA1
規(guī)格：
來(lái)源：

Baculovirus
其他：

中文名稱：

大鼠Mep1b重組蛋白
貨號(hào)：

CSB-MP013702RA1
規(guī)格：
來(lái)源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Mep1b
Uniprot No.：

P28826
別名：

Mep1b; Meprin A subunit beta; Endopeptidase-2; Meprin B
種屬：

Rattus norvegicus (Rat)
蛋白長(zhǎng)度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1' position. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components.
基因功能參考文獻(xiàn)：
1. A model of the meprin B dimer structure is proposed that provides insight into the relationship between structure and function of this isoform. PMID: 15695509
2. In anti-Thy 1.1 glomerulonephritis we observed striking redistribution of meprin beta in tubular epithelial cells from the apical to the basolateral side and the cytosol. This might point to an involvement of meprin beta in this form of glomerulonephritis PMID: 18509531
3. identifies proIL-18 as a biologically important substrate for meprin beta and implicates meprins in the modulation of inflammation PMID: 18786924
亞細(xì)胞定位：

Cell membrane; Single-pass type I membrane protein. Secreted.
蛋白家族：

Peptidase M12A family
組織特異性：

Kidney, intestinal brush borders and salivary ducts.
數(shù)據(jù)庫(kù)鏈接：

KEGG: rno:25727

STRING: 10116.ENSRNOP00000063916

UniGene: Rn.3520