Recombinant Rat Glutamate receptor 3 (Gria3), partial

中文名稱：

大鼠Gria3重組蛋白
貨號：

CSB-YP009900RA
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Gria3重組蛋白
貨號：

CSB-EP009900RA
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Gria3重組蛋白
貨號：

CSB-EP009900RA-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Gria3重組蛋白
貨號：

CSB-BP009900RA
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Gria3重組蛋白
貨號：

CSB-MP009900RA
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Gria3
Uniprot No.：

P19492
別名：

Gria3; Glur3Glutamate receptor 3; GluR-3; AMPA-selective glutamate receptor 3; GluR-C; GluR-K3; Glutamate receptor ionotropic; AMPA 3; GluA3
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
基因功能參考文獻：
1. This study showed that GluA3 is uniformly distributed along the synapse, and seldom extends beyond its lateral border in hippocamoys. PMID: 25524891
2. A decrease in GluA1 and increases in GluA3 subunit and TARP expression at the end of the third postnatal week provide a molecular explanation for the increase in AMPAR response duration and reduced efficacy of AMPAR modulators with increasing age. PMID: 23884930
3. GluR2/3 is translocated into the intracellular pool following brain ischemia-reperfusion. PMID: 23212166
4. Bushy cells and fusiform cells upregulated GluA3 and downregulated GlyRalpha1 expression following 7 days of monaural conductive hearing loss PMID: 22044924
5. Using the cue-induced reinstatement and alcohol deprivation effect paradigms, we could show that the GluR-C subunit is involved in alcohol seeking and relapse [GluR-C] PMID: 16436610
6. AMPA3 receptors co-localize with AMPA2 receptors in the caudal nucleus tractus solitarius at pre- and postsynaptic sites and in astrocytic glia, and may co-localize with AMPA1 receptor subunits in large dendrites. PMID: 12470884
7. Following retinal ischemia the decrease in GluR3 labeling intensity is most profound at 4 h; the recovery of GluR3 staining intensity is slow, and staining is still decreased at 7 days. PMID: 14706873
8. The results of this study indicate a possible role for changes in AMPA receptor subunit expression in NTS neurones, involving an increase in GluR3 associated with development of hypertension in SH. PMID: 14969735
9. GluR3 is targeted to lysosomes regardless of NMDA receptor activation. PMID: 15260958
10. GluR3 receptors are frequently found not only on postsynaptic but also on presynaptic profiles immunopositive for VGluT1 and VGluT2 in the neostriatum. PMID: 15610164
11. the alternative splicing that generates flip and flop variants of GluR3 receptors regulates the channel opening process by controlling the rate of channel closing but not the rate of channel opening or the glutamate binding affinity PMID: 17256974
12. Chronic intermittent hypoxia impairs heart rate responses to AMPA and NMDA and induces loss of GluR3 neurons in nucleus ambiguous of F344 rats. PMID: 19020286
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亞細胞定位：

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Interaction with CNIH2 and CNIH3 promotes cell surface expression.
蛋白家族：

Glutamate-gated ion channel (TC 1.A.10.1) family, GRIA3 subfamily
數據庫鏈接：

KEGG: rno:29628

STRING: 10116.ENSRNOP00000031170

UniGene: Rn.74049