Recombinant Rat Fos-related antigen 1 (Fosl1)

中文名稱：

大鼠Fosl1重組蛋白
貨號：

CSB-YP008792RA
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Fosl1重組蛋白
貨號：

CSB-EP008792RA
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Fosl1重組蛋白
貨號：

CSB-EP008792RA-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Fosl1重組蛋白
貨號：

CSB-BP008792RA
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Fosl1重組蛋白
貨號：

CSB-MP008792RA
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Fosl1
Uniprot No.：

P10158
別名：

Fosl1; Fra1Fos-related antigen 1; FRA-1
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full length protein
表達區域：

1-275
氨基酸序列

MYRDFGEPGP SSGAGSAYGR PAQPQQAQTQ TVQQQKFHLV PSINAVSGSQ ELQWMVQPHF LGPSGYPRPL TYPQYSPPQP RPGVIRALGP PPGVRRRPCE QISPEEEERR RVRRERNKLA AAKCRNRRKE LTDFLQAETD KLEDEKSGLQ REIEELQKQK ERLELVLEAH RPICKIPEED KKDTGGTSST SGAGSPPGPC RPVPCISLSP GPVLEPEALH TPTLMTTPSL TPFTPSLVFT YPSTPEPCSS AHRKSSSSSG DPSSDPLGSP TLLAL
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

基因功能參考文獻：
1. FOSL1 recruits JUNB to form AP-1 transcriptional complexes that specifically regulate the endocrine and invasive trophoblast phenotypes. PMID: 26149388
2. is regulated in cardia myoblasts by cellular redox through multiple cis-regulatory modules PMID: 21820506
3. FOSL1 is integral to establishing the maternal-fetal interface PMID: 21947281
4. Data show that bladder wall distension leads to PDGF receptor activation and identify thrombomodulin as an Akt and Fra-1 target in smooth muscle cells. PMID: 20472895
5. demonstrated that a functional AP-1 site mediates MMP-2 transcription in cardiac cells through the binding of distinctive Fra1-JunB and FosB-JunB heterodimers. The synthesis of MMP-2 is considered to be independent of the AP-1 transcriptional complex. PMID: 12371906
6. Fra1 is able to stimulate a heterologous promoter in a ras-dependent manner, but its transactivating activity requires the recruitment of a heterodimeric partner PMID: 12773579
7. Microarray analysis and RNA silencing link this protein to cd44 and c-met expression in mesothelioma. PMID: 12839939
8. Overexpression of fra-1 leading to proliferation inhibition of C6 glioma cells is consistent with the concept that fra-1 functions as a negative regulator of AP-1 activity. PMID: 14597411
9. plays key role in remodelling phenomena of bone and cartilage PMID: 16373449
10. Sustained increased expression of Fra-1 in the hippocampus after instrumental overtraining could reflect a possible role of dopaminergic neurons in habit formation. PMID: 16377429
11. Fra-1 induction is important in thyroid tumorigenesis, critically regulating cyclin expression and cell-cycle progression. PMID: 17347653
12. Corticosterone produced an early and transient reduction of fra-1 mRNA levels exclusively in the rat dentate gyrus. PMID: 18485334
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亞細胞定位：

Nucleus.
蛋白家族：

BZIP family, Fos subfamily
數據庫鏈接：

KEGG: rno:25445

STRING: 10116.ENSRNOP00000027891

UniGene: Rn.11306