Recombinant Rat Ectonucleoside triphosphate diphosphohydrolase 2 (Entpd2), partial

中文名稱：

大鼠Entpd2重組蛋白
貨號：

CSB-YP007691RA1
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

大鼠Entpd2重組蛋白
貨號：

CSB-EP007691RA1
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

大鼠Entpd2重組蛋白
貨號：

CSB-EP007691RA1-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Entpd2重組蛋白
貨號：

CSB-BP007691RA1
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Entpd2重組蛋白
貨號：

CSB-MP007691RA1
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
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靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Entpd2
Uniprot No.：

O35795
別名：

Entpd2; Cd39l1; Ectonucleoside triphosphate diphosphohydrolase 2; NTPDase 2; CD39 antigen-like 1
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent.
基因功能參考文獻：
1. Apo and complex structures of the rat NTPDase2 extracellular domain and Legionella pneumophila NTPDase1. PMID: 23830739
2. two ENTPD isoforms, ENTPD-1 and -2, are expressed in adult rat ventricular CFs PMID: 23677997
3. NTPDase2 overexpression modulates pro-inflammatory cytokine production and platelet reactivity. PMID: 22038661
4. ATP acts in an autocrine manner to promote its own release and that of dopamine, an action that is controlled by the level of E-NTPDase1/CD39 expression PMID: 21325440
5. NTPDase2 was expressed in the periportal region surrounding intrahepatic bile ducts PMID: 12395323
6. novel inducible release of full length particulate CD39, and propose its role in the physiological context of pancreatic secretion. PMID: 12832497
7. NTPDase2 is associated with nonmyelinating Schwann cells of the rat sciatic nerve. It was associated with the satellite glial cells in dorsal root ganglia and sympathetic ganglia, and with the enteric ganglion glia. PMID: 14730706
8. hepatic stellate cells differentially regulate nucleoside triphosphate diphosphohydrolase expression after activation PMID: 14764443
9. the amplitude of the long-lasting phase of the Ca(2+) signal depended on the balance between agonist degradation by ectonucleotidases and agonist transport, by diffusion and convection, from bulk solution to the EC surface PMID: 15004436
10. alternative coding of the intracellular C-terminal domain contributes distinctive phenotypic variation with respect to extracellular nucleotide specificity, hydrolysis kinetics, protein kinase-dependent intracellular regulation and protein trafficking PMID: 15362980
11. down-regulation in biliary cirrhosis PMID: 15651265
12. NTPDase2 has a role in portal fibroblast regulation of bile duct epithelium proliferation PMID: 15799977
13. NTPDase2 may modulate inflammatory reactions within the central nervous system and could represent a useful therapeutic target in human disease. PMID: 16414200
14. NTPdase2 expression profile was studied in the Walker 256 carcinoma. PMID: 17574764
15. NTPDase2 ectodomain refolded from bacterial inclusion bodies was characterized. PMID: 17910474
16. Data showed that Entpd2 as the enzyme with the highest expression in left ventricle. PMID: 18201730
17. IL-6 transcriptionally downregulates NTPDase2 expression by portal fibroblasts via actions at specific promoter elements independently of myofibroblastic differentiation PMID: 18202114
18. The structure of the extracellular domain of Rattus norvegicus NTPDase2 in an active state at resolutions between 1.7 A and 2.1 A in four different forms, is presented. PMID: 18458329
19. Selective NTPDase2 expression modulates in vivo rat glioma growth. PMID: 19558578
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亞細胞定位：

[Isoform 1]: Cell membrane; Multi-pass membrane protein.
蛋白家族：

GDA1/CD39 NTPase family
組織特異性：

Expressed in brain, heart, vas deferens, kidney, skeletal muscle, thymus, lung and spleen. Weak expression in liver.
數(shù)據(jù)庫鏈接：

KEGG: rno:64467

STRING: 10116.ENSRNOP00000017829

UniGene: Rn.8276