Recombinant Rat E3 ubiquitin-protein ligase MGRN1 (Mgrn1)

中文名稱：

大鼠Mgrn1重組蛋白
貨號：

CSB-YP736462RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

大鼠Mgrn1重組蛋白
貨號：

CSB-EP736462RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

大鼠Mgrn1重組蛋白
貨號：

CSB-EP736462RA-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Mgrn1重組蛋白
貨號：

CSB-BP736462RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Mgrn1重組蛋白
貨號：

CSB-MP736462RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Mgrn1
Uniprot No.：

Q5XIQ4
別名：

Mgrn1; E3 ubiquitin-protein ligase MGRN1; EC 2.3.2.27; Mahogunin RING finger protein 1; RING-type E3 ubiquitin transferase MGRN1
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full Length of Mature Protein
表達(dá)區(qū)域：

2-533
氨基酸序列

GSILSRRIA GVEDIDIQAN SAYRYPPKSA GNYFASHFFM GGEKFDTPHP EGYLFGENMD LNFLGSRPVQ FPYVTPAPHE PVKTLRSLVN IRKDSLRLVR YKDDTDSPTE DGEKPRVLYS LEFTFDADAR VAITIYCQAV EEFVNGMTVY SCKNPSLQSE TVHYKRGVSQ QFSLPSFKID FSEWKDDELN FDLDRGVFPV VIQAVVDEGD VVEVTGHAHV LLAAFEKHVD GSFSVKPLKQ KQIVDRVSYL LQEIYGIENK NNQETKPSDD ENSDNSSECV VCLSDLRDTL ILPCRHLCLC TSCADTLRYQ ANNCPICRLP FRALLQIRAV RKKPGALSPI SFSPVLAQSV DHDEHSNSDS VPPGYEPISL LEALNGLRAV SPAIPSAPLY EEITYSGISD GLSQASCPLA GLDRIIENGI QKGKTQSKSP DSTLRSPSSP IHEEDEEKLS EDPEAPLPPS GVELVLQESS SPESFGTEEV GEPSLKQGSR VPSIDDVLQD GSPQHHGCSQ PVPPADIYLP ALGPESCSVG IEE
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

E3 ubiquitin-protein ligase. Mediates TSG101 monoubiquitination at multiple sites. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling.
基因功能參考文獻(xiàn)：
1. With aging, the neuroprotective e3 ligase MGRN1 relocates from the cytosol to the nucleus of neurons, where it associates with chromatin and potentiates the cellular response to proteotoxic stress. This nuclear shift is due to a proteasome impairment dependent increase of a monoubiquitinated form of MGRN1. PMID: 28475871
亞細(xì)胞定位：

Cytoplasm, cytosol. Cell membrane. Early endosome.
數(shù)據(jù)庫鏈接：

KEGG: rno:302938

STRING: 10116.ENSRNOP00000004416

UniGene: Rn.15530