Recombinant Rat Cytoplasmic polyadenylation element-binding protein 1 (Cpeb1)

中文名稱：

Recombinant Rat Cytoplasmic polyadenylation element-binding protein 1(Cpeb1)
貨號：

CSB-YP005887RA
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Rat Cytoplasmic polyadenylation element-binding protein 1(Cpeb1)
貨號：

CSB-EP005887RA
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Rat Cytoplasmic polyadenylation element-binding protein 1(Cpeb1)
貨號：

CSB-EP005887RA-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Rat Cytoplasmic polyadenylation element-binding protein 1(Cpeb1)
貨號：

CSB-BP005887RA
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Rat Cytoplasmic polyadenylation element-binding protein 1(Cpeb1)
貨號：

CSB-MP005887RA
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Cpeb1
Uniprot No.：

P0C279
別名：

Cpeb1Cytoplasmic polyadenylation element-binding protein 1; CPE-BP1; CPE-binding protein 1; CPEB; CPEB-1
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full length protein
表達區域：

1-561
氨基酸序列

MAFSLEEESG RIKDCWDNQE VPALSTCSNA NIFRRINAIL DDSLDFSKVC TTPINRGIHD QLPDFQDSEE AITSRMLFPT SAQESPRGLP DANGLCLGLQ SLSLTGWDRP WSTQDSDSSA QSNTQSVLSM LQNPLGNVLG KTPLSFLSLD PLGSDLDKFP APSVRGSRLD TRPILDSRSS SPSDSDTSGF SSGSDHLSDL ISSLRISPPL PFLSMTGNGP RDPLKMGVGS RMDQEQAALA AVAPSPTSAP KRWPGTSVWP SWDLLGAPKD PFSIEREARL HRQAAAVNEA TCTWSGQLPP RNYKNPIYSC KVFLGGVPWD ITEAGLVNTF RVFGSLSVEW PGKDGKHPRC PPKGNMPKGY VYLVFELEKS VRALLQACSH DPLSPDGLSE YYFKMSSRRM RCKEVQVIPW VLADSNFVWS PSQRLDPSRT VFVGALHGML NAEALAAILN DLFGGVVYAG IDTDKHKYPI GSGRVTFNNQ RSYLKAVTAA FVEIKTTKFT KKVQIDPYLE DSLCLICSSQ PGPFFCRDQV CFKYFCRSCW HWRHSMEGLR HHSPLMRNQK N
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the 3'-UTR of mRNAs. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation. Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses. Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation. Induces the assembly of stress granules in the absence of stress. Required for cell cycle progression, specifically for prophase entry.
基因功能參考文獻：
1. Increased NPCs proliferation by down-regulation of CPEB1 resulted in eventual up-regulation of neuronal differentiation with increase in both pre- and post-synaptic proteins PMID: 23824559
2. This study demonistrated that in chronic mild stress and acute sleep deprivation condition regulation CPEB expressin in hippocampus. PMID: 22917528
3. poly(A) polymerase Gld2, deadenylase PARN, and translation inhibitory factor neuroguidin (Ngd) are components of a dendritic CPEB-associated polyadenylation apparatus PMID: 22727665
4. CPEB is downstream of protein kinase Cepsilon in the cellular signaling cascade responsible for priming the induction of hyperalgesia. PMID: 22323716
5. Results demonstrate for the first time a role for CPEB1 in regulating cell proliferation in the brain. PMID: 21865454
6. The results from the study suggest that CPEB1 is actively involved in the regulation of inflammatory responses in astrocytes, which might provide new insights into the regulatory mechanism after brain injury. PMID: 21620800
7. CPEB1 mediates protein synthesis in the localization of beta-catenin protein to the leading edge of migrating astrocytes, and has a role in regulating directed cell motility. PMID: 18618654
8. these results suggest that CPEB1 regulates beta-catenin synthesis in neurons and may contribute to neuronal morphogenesis PMID: 19864575
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亞細胞定位：

Cytoplasm. Cell junction, synapse. Cytoplasm, P-body. Cytoplasmic granule. Membrane. Cell junction, synapse, postsynaptic density.
蛋白家族：

RRM CPEB family
組織特異性：

Expressed in hippocampus and cerebral cortex (at protein level). Expressed in hippocampus (dentate gyrus and CA1-CA4 regions), cerebellum (Purkinje cells), cortex, visual cortex (layers 1 and 2), mesencephalon, diencephalon and brain stem.
數據庫鏈接：

KEGG: rno:293056

STRING: 10116.ENSRNOP00000026009

UniGene: Rn.224485