Recombinant Rat Carboxypeptidase E (Cpe)

中文名稱：

Recombinant Rat Carboxypeptidase E(Cpe)
貨號：

CSB-YP005886RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Rat Carboxypeptidase E(Cpe)
貨號：

CSB-EP005886RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

Recombinant Rat Carboxypeptidase E(Cpe)
貨號：

CSB-EP005886RA-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Rat Carboxypeptidase E(Cpe)
貨號：

CSB-BP005886RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Rat Carboxypeptidase E(Cpe)
貨號：

CSB-MP005886RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Cpe
Uniprot No.：

P15087
別名：

Cpe; Carboxypeptidase E; CPE; EC 3.4.17.10; Carboxypeptidase H; CPH; Enkephalin convertase; Prohormone-processing carboxypeptidase
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full Length of Mature Protein
表達(dá)區(qū)域：

43-476
氨基酸序列

LQQEDGIS FEYHRYPELR EALVSVWLQC TAISRIYTVG RSFEGRELLV IELSDNPGVH EPGEPEFKYI GNMHGNEAVG RELLIFLAQY LCNEYQRGNE TIVNLIHSTR IHIMPSLNPD GFEKAASQPG ELKDWFVGRS NAQGIDLNRN FPDLDRIVYV NEKEGGPNNH LLKNLKKIVD QNSKLAPETK AVIHWIMDIP FVLSANLHGG DLVANYPYDE TRSGTAHEYS SCPDDAIFQS LARAYSSFNP VMSDPNRPPC RKNDDDSSFV DGTTNGGAWY SVPGGMQDFN YLSSNCFEIT VELSCEKFPP EETLKSYWED NKNSLINYLE QIHRGVKGFV RDLQGNPIAN ATISVDGIDH DVTSAKDGDY WRLLVPGNYK LTASAPGYLA ITKKVAVPFS PAVGVDFELE SFSERKEEEK EELMEWWKMM SETLNF
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage.
基因功能參考文獻(xiàn)：
1. The neuroprotective effect of CPE-DeltaN against neuronal glutamate neurotoxicity was mediated by secreted FGF2. PMID: 25426952
2. Data indicate that secreted carboxypeptidase E (CPE) promotes PC12 cell survival under metabolic stress. PMID: 23941827
3. These results reveal a novel role for CPE in the regulation of DAT trafficking and DAT-mediated dopamine uptake. PMID: 19419578
4. The carboxypeptidase E (CPE) is involved in gut hormone processing and is not presence in gut endocrine cells. PMID: 14661109
5. Data suggest that ischemia has an adverse impact on the neuropeptide-processing system in the brain and that the lack of an active carboxypeptidase E neuropeptide-processing enzyme exacerbates ischemic brain injury. PMID: 15181368
6. SgIII and CPE form the separate functional sorting complex by anchoring to cholesterol-rich SG membranes, and POMC-derived peptides are transferred from CPE to SgIII, and subsequently to CgA. PMID: 16219686
7. Data show that the carboxypeptidase E cytoplasmic tail binds dynactin that recruits kinesins or dynein for driving bi-directional transport of BDNF vesicles to maintain vesicle homeostasis and secretion in hippocampal neurons. PMID: 18573344
8. CPE expression levels were compared among mature retina tissue, RGC-5 cells and its differentiated cells; more CPE and preproNPY protein expression in the tumor cells or tumor tissue were observed PMID: 19428990
9. CPE mediates the effects of NOS1AP on dendrite morphology. PMID: 19553464
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亞細(xì)胞定位：

Cytoplasmic vesicle, secretory vesicle. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Secreted.
蛋白家族：

Peptidase M14 family
組織特異性：

Expressed in brain, heart and anterior pituitary gland. Also expressed in pancreatic islets and adrenal gland.
數(shù)據(jù)庫鏈接：

KEGG: rno:25669

UniGene: Rn.7149