Recombinant Rat Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Pde1c)

中文名稱：

大鼠Pde1c重組蛋白
貨號：

CSB-YP720512RA
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Pde1c重組蛋白
貨號：

CSB-EP720512RA-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Pde1c重組蛋白
貨號：

CSB-BP720512RA
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Pde1c重組蛋白
貨號：

CSB-MP720512RA
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Pde1c
Uniprot No.：

Q63421
別名：

Pde1c; Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C; Cam-PDE 1C; 3',5'-cyclic-AMP phosphodiesterase; EC 3.1.4.-; 3',5'-cyclic-GMP phosphodiesterase; EC 3.1.4.35
種屬：

Rattus norvegicus (Rat)
蛋白長度：

full length protein
表達區域：

1-768
氨基酸序列

MTDTSHKKEG FKKCRSATFS IDGYSFTIVA NEAGDKNARP LARFSRSKSQ NCLWNSLIDG LTGNVKEKPR PTIVQDTRPP EEILADELPQ LDSPEALVKT SFRLRSLVKQ LERGEASVVD LKKNLEYAAT VLESVYIDET RRLLDTEDEL SDIQSDAVPS EVRDWLASTF TRQMGMMLRR SDEKPRFKSI VHAVQAGIFV ERMYRRTSNM VGLSYPPAVI DALKDVDTWS FDVFSLNEAS GDHALKFIFY ELLTRYDLIS RFKIPISALV SFVEALEVGY SKHKNPYHNL MHAADVTQTV HYLLYKTGVA NWLTELEIFA IIFSAAIHDY EHTGTTNNFH IQTRSDPAIL YNDRSVLENH HLSAAYRLLQ EDEEMNILVN LSKDDWREFR TLVIEMVMAT DMSCHFQQIK AMKTALQQPE AIEKPKALSL MLHTADISHP AKAWDLHHRW TMSLLEEFFR QGDREAELGL PFSPLCDRKS TMVAQSQVGF IDFIVEPTFT VLTDMTEKIV SPLIDETSQT GGTGQRRSSL NSINSSDAKR SGVKSSGSEG SAPINNSVIP VDYKSFKATW TEVVQINRER WRAKVPKEEK AKKEAEEKAR LAAEEKQKEM EAKSQAEQGT TSKAEKKTSG ETKGQVNGTR TSKGDNPRGK NSKGDKAGEK QQNGDLKDGK NKADKKDHSN TGNESKKADG TKKRSHGSPA PSTSSTSRLT LPVIKPPLRH FKRPAYASSS YAPSVPKKTD DHPVRYKMLD QRIKIKKIQN ISHHWNKK
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP. Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB.
基因功能參考文獻：
1. In cultured rat aortic SMCs, PDE1C deficiency or PDE1 inhibition attenuated SMC proliferation and migration. PDE1C plays a critical role in regulating the stability of growth factor receptors, endocytosis and lysosome-dependent degradation. PMID: 25608528
2. Suggest that PDE1C plays a critical role in regulating collagen homeostasis during pathological vascular remodeling. PMID: 21148428
蛋白家族：

Cyclic nucleotide phosphodiesterase family, PDE1 subfamily
組織特異性：

Highly expressed in olfactory epithelium and at moderate levels, in cerebellum, as well as weakly in forebrain, testis, heart and lung. In the olfactory epithelium, expressed by sensory neurons, but not epithelial cells.
數據庫鏈接：

KEGG: rno:81742

STRING: 10116.ENSRNOP00000017531

UniGene: Rn.10289