Recombinant Rat COMM domain-containing protein 5 (Commd5)

中文名稱：

Recombinant Rat COMM domain-containing protein 5(Commd5)
貨號：

CSB-YP880645RA
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Rat COMM domain-containing protein 5(Commd5)
貨號：

CSB-EP880645RA-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Rat COMM domain-containing protein 5(Commd5)
貨號：

CSB-MP880645RA
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Commd5
Uniprot No.：

Q9ERR2
別名：

Commd5; COMM domain-containing protein 5; Hypertension-related calcium-regulated gene protein; HCaRG
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full Length of Mature Protein
表達區域：

2-224
氨基酸序列

SALGAAAPY LHHPADSHSG RVSFLGSQPS PEVTAVAQLL KDLDRSTFRK LLKLVVGALH GKDCREAVEQ LGASANLSEE RLAVLLAGTH TLLQQALRLP PASLKPDAFQ EELQELGIPQ DLIGDLASLA FGSQRPLLDS VAQQQGSSLP HVSYFRWRVD VAISTSAQSR SLQPSVLMQL KLTDGSAHRF EVPIAKFQEL RYSVALVLKE MAELEKKCER KLQD
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis. Down-regulates activation of NF-kappa-B.
基因功能參考文獻：
1. Hcarg localizes to the rat chromosome 7 between the markers Mit3 and Mit4. We identified a BglII RFLP between BN.lx and SHR rats. PMID: 11871861
2. HCaRG regulates renal epithelial cell growth and differentiation causing G(2)M cell cycle arrest PMID: 12620924
3. data support a role for HCaRG in kidney repair after injury through its effect on renal cell migration and TGF-alpha secretion PMID: 16033922
4. The up-regulation of HCaRG may be one of the mechanisms underlying the chemopreventive effect of rosiglitazone in gastric cancer. PMID: 18949406
亞細胞定位：

Nucleus.
組織特異性：

Expressed in the zona fasciculata and medulla of the adrenal gland; expressed in kidney proximal tubules. Basal expression is higher in hypertensive than in normotensive animals.
數據庫鏈接：

KEGG: rno:245974

STRING: 10116.ENSRNOP00000065036

UniGene: Rn.24747