Recombinant Rat CCAAT/enhancer-binding protein alpha (Cebpa)

中文名稱：

Recombinant Rat CCAAT/enhancer-binding protein alpha(Cebpa)
貨號：

CSB-YP005180RA
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Rat CCAAT/enhancer-binding protein alpha(Cebpa)
貨號：

CSB-EP005180RA
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Rat CCAAT/enhancer-binding protein alpha(Cebpa)
貨號：

CSB-EP005180RA-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Rat CCAAT/enhancer-binding protein alpha(Cebpa)
貨號：

CSB-BP005180RA
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Rat CCAAT/enhancer-binding protein alpha(Cebpa)
貨號：

CSB-MP005180RA
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Cebpa
Uniprot No.：

P05554
別名：

CebpaCCAAT/enhancer-binding protein alpha; C/EBP alpha
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full length protein
表達區域：

1-358
氨基酸序列

MESADFYEAE PRPPMSSHLQ SPPHAPSNAA FGFPRGAGPA PPPAPPAAPE PLGGICEHET SIDISAYIDP AAFNDEFLAD LFQHSRQQEK AKAAAGPAGG GGDFDYPGAP AGPGGAVMSA GAHGPPPGYG CAAAGYLDGR LEPLYERVGA PALRPLVIKQ EPREEDEAKQ LALAGLFPYQ PPPPPPPPHP HASPAHLAAP HLQFQIAHCG QTTMHLQPGH PTPPPTPVPS PHPAPAMGAA GLPGPGGSLK GLAGPHPDLR TGGGGGGGAG AGKAKKSVDK NSNEYRVRRE RNNIAVRKSR DKAKQRNVET QQKVLELTSD NDRLRKRVEQ LSRELDTLRG IFRQLPESSL VKAMGNCA
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta. Binds directly to the consensus DNA sequence 5'-TCan act as dominant-negative. Binds DNA and have transctivation activity, even if much less efficiently than isoform 2. Does not inhibit cell proliferation.; Directly and specifically enhances ribosomal DNA transcription interacting with RNA polymerase I-specific cofactors and inducing histone acetylation.
基因功能參考文獻：
1. C/EBPalpha played a role in lung development and provided the insight into the mechanism underlying SUMO-modification. PMID: 28902364
2. The differential regulation of hepcidin between young and old rats after hyperthermia may be due to the enhanced expression of C/EBPalpha protein in old rats. PMID: 23993269
3. IL-13-enhanced PLA2 activity regulates COX-2/PGE2 expression through C/EBP-alpha activation. PMID: 23881867
4. HDAC3 interacts with sumoylated CEBPalpha to negatively regulate the LXRalpha expression. PMID: 23639777
5. This study indicated, for the first time, that diabetes mellitus altered the immunoreactivity of C/EBPs in the nervous system. PMID: 23508841
6. the basic region and leucine zipper (BZip) domain of C/EBPalpha is sufficient for the interaction with HP1alpha in regions of heterochromatin PMID: 23392382
7. Angelica sinensis polysaccharide downregulated hepcidin by repressing CCAAT/enhancer-binding protein alpha and the phosphorylation of signal transducer and activator of transcription 3/5. PMID: 22985399
8. In rats subjected to intermittent fasting, PPARgamma2 and C/EBPalpha mRNA expression in white adipose tissue was increased, and there was a positive correlation of Fsp27 gene expression with PPARgamma2 and C/EBPalpha mRNA levels. PMID: 21996045
9. in pleural mesothelioma, p38 delta and C/EBP-alpha mediate proliferation and thus may represent new targets in mesothelioma therapy PMID: 21227534
10. iNOS promoter was the direct transcriptional target of the C/EBPalpha, C/EBPbeta, and NF-kappaB binding proteins in hepatocytes PMID: 21539866
11. C/EBPalpha down-regulation may be one mechanism of reduced hepatocyte viability in cultured hypoxic rat primary hepatocytes PMID: 20219337
12. Protein level of C/EBPalpha in lung of the STZ-diabetic rats was similar as the normal rats. PMID: 21249617
13. C/EBPalpha, in cooperation with NFAT, directly regulates Il4 gene transcription. PMID: 21454593
14. role in regulating hepatic transcription of hepcidin PMID: 12183449
15. Transiently expressed C/EBPalpha induced PRL gene transcription in pituitary GHFT1-5 cells, whereas the coexpression of Pit-1 and C/EBPalpha in HeLa cells demonstrated their cooperativity at the PRL promoter PMID: 12554749
16. Results of x-ray structure analysis of a C/EBPalpha bZIP polypeptide bound to its cognate DNA site and engineered amino acid substitutions provide the first detailed description of DNA recognition by a C/EBP family member. PMID: 12578822
17. CEBPa has a role in regulating lipogenic enzymes and transport proteins stimulated by keratinocyte growth factor in type II alveolar cells PMID: 12865412
18. Results describe the temporal relationships and role of CCAAT/enhancing-binding protein alpha, sterol regulatory element binding protein-1c, and stearoyl-CoA desaturase 1 in lipogenesis in fetal rat lung PMID: 12896875
19. the anti-proliferation activity of C/EBPalpha critically depends on components of the SWI/SNF core complex PMID: 14660596
20. C-EBP alpha has a role in the activation phenotype of hepatic stellate cells. PMID: 15504357
21. Results show that in addition to its previously recognized function in suppressing PPARgamma transcriptional activity, interaction of GATA-2 and -3 with C/EBP is necessary for their ability to negatively regulate adipogenesis. PMID: 15632071
22. Haptoglobin gene transcription is regulated by C/EBP alpha during normal liver development. PMID: 16172914
23. A negative regulator of placental glutathione S-transferase gene expression in normal liver. PMID: 16407263
24. the domain containing threonines 222/226 has a role in regulating C/EBPalpha activity in adipocytes but not hepatocytes, and GSK3 phosphorylation of these residues does not mediate regulation of this C/EBP activity PMID: 16600022
25. In LNCaP cells C/EBPalpha over expression inhibits expression of prostate specific antigen by Androgen receptor-dependent mechanism PMID: 16774685
26. HNF4alpha, CREM, HNF1alpha, and C/EBPalpha have roles in transcriptional regulation of the glucose-6-phosphatase gene by cAMP/vasoactive intestinal peptide in the intestine PMID: 16893891
27. Data suggested that both the initiating and maintaining of differentiation process were regulated by PPARgamma, while C/EBPalpha was likely to participate in the maintaining of differentiation process only. PMID: 17966466
28. Binds and activates the endogenous PU.1 (Spi-1) promoter, providing one mechanism for induction of monopoiesis. PMID: 18026136
29. temporo-spatial expression pattern of the transcription factor C/EBPalpha, a key player in adipocyte differentiation PMID: 18328085
30. The results indicated that the death receptor pathway was mainly involved and regulated by PPAR-gamma and p53 in the process of apoptosis triggered by C/EBP-alpha in hepatic stellate cells. PMID: 19168033
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亞細胞定位：

Nucleus.; [Isoform 4]: Nucleus, nucleolus.
蛋白家族：

BZIP family, C/EBP subfamily
組織特異性：

Isoform 2 and isoform 3 are expressed in liver (at protein level).
數據庫鏈接：

KEGG: rno:24252

STRING: 10116.ENSRNOP00000063123