Recombinant Rat Adenylate cyclase type 8 (Adcy8), partial

中文名稱：

Recombinant Rat Adenylate cyclase type 8(Adcy8) ,partial
貨號：

CSB-YP001344RA
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Rat Adenylate cyclase type 8(Adcy8) ,partial
貨號：

CSB-EP001344RA
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Rat Adenylate cyclase type 8(Adcy8) ,partial
貨號：

CSB-EP001344RA-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Rat Adenylate cyclase type 8(Adcy8) ,partial
貨號：

CSB-BP001344RA
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Rat Adenylate cyclase type 8(Adcy8) ,partial
貨號：

CSB-MP001344RA
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Adcy8
Uniprot No.：

P40146
別名：

Adcy8Adenylate cyclase type 8; EC 4.6.1.1; ATP pyrophosphate-lyase 8; Adenylate cyclase type VIII; Adenylyl cyclase 8; Ca(2+)/calmodulin-activated adenylyl cyclase
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion. Plays a role in many brain functions, such as learning, memory, drug addiction, and anxiety modulation through regulation of synaptic plasticity by modulating long-term memory and long-term potentiation (LTP) through CREB transcription factor activity modulation. Plays a central role in insulin secretion by controlling glucose homeostasis through glucagon-like peptide 1 and glucose signaling pathway and maintains insulin secretion through calcium-dependent PKA activation leading to vesicle pool replenishment. Also, allows PTGER3 to induce potentiation of PTGER4-mediated PLA2 secretion by switching from a negative to a positive regulation, during the IL1B induced-dedifferentiation of smooth muscle cells.
基因功能參考文獻：
1. Data show that the IL-1beta-dependent transdifferentiation of VSMCs is associated with the de novo expression of a new family of AC8 isoforms. These isoforms are catalytically inactive with dominant-negative effects, decreasing total cAMP production. The inhibitory effect of AC8E on adenylyl cyclases (ACs) activity is accompanied by the formation of heterodimers between AC8E and functional ACs. PMID: 29940197
2. Despite previous hints pointing to a major contribution of ACs, the presented data show that there is no apparent causality between AC activity and the occurrence of the epileptic phenotype. PMID: 22531884
3. AC8 expression, besides being induced by the proinflammatory cytokine IL1beta, is also dependent on down-regulation of the Notch pathway occurring in an inflammatory context. PMID: 22613711
4. Mutation of the two critical cysteines results in exclusion of AKAP79 from lipid rafts and alterations in its membrane diffusion behavior and is accompanied by a loss of the ability of AKAP79 to regulate AC8. PMID: 21771783
5. Integration of PGE2 signals depend on the upregulation of calcium/calmodulin stimulable adenylyl cyclase 8. PMID: 16741924
6. Distinct mechanisms of regulation by Ca2+/calmodulin of type 1 and 8 adenylyl cyclases support their different physiological roles. PMID: 19029295
7. An IQ-like motif imparts calmodulin binding and autoinhibitory functions to adenylyl cyclcase 8. PMID: 19305019
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亞細胞定位：

Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Membrane raft. Membrane, coated pit. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Membrane, caveola. Basolateral cell membrane. Apical cell membrane. Cell junction, synapse. Cell projection, dendrite. Cell projection, axon. Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, postsynaptic density.
蛋白家族：

Adenylyl cyclase class-4/guanylyl cyclase family
組織特異性：

Brain. Expressed in insulin-producing cells.
數據庫鏈接：

KEGG: rno:29241

STRING: 10116.ENSRNOP00000006789

UniGene: Rn.10382