Recombinant Rabbit Cellular tumor antigen p53 (TP53)

中文名稱：

小圓錐花果TP53重組蛋白
貨號：

CSB-YP856773RB
規格：
來源：

Yeast
其他：

中文名稱：

小圓錐花果TP53重組蛋白
貨號：

CSB-EP856773RB
規格：
來源：

E.coli
其他：

中文名稱：

小圓錐花果TP53重組蛋白
貨號：

CSB-EP856773RB-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小圓錐花果TP53重組蛋白
貨號：

CSB-BP856773RB
規格：
來源：

Baculovirus
其他：

中文名稱：

小圓錐花果TP53重組蛋白
貨號：

CSB-MP856773RB
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

TP53
Uniprot No.：

Q95330
別名：

TP53; Cellular tumor antigen p53; Tumor suppressor p53
種屬：

Oryctolagus cuniculus (Rabbit)
蛋白長度：

full length protein
表達區域：

1-391
氨基酸序列

MEESQSDLSL EPPLSQETFS DLWKLLPENN LLTTSLNPPV DDLLSAEDVA NWLNEDPEEG LRVPAAPAPE APAPAAPALA APAPATSWPL SSSVPSQKTY HGNYGFRLGF LHSGTAKSVT CTYSPCLNKL FCQLAKTCPV QLWVDSTPPP GTRVRAMAIY KKSQHMTEVV RRCPHHERCS DSDGLAPPQH LIRVEGNLRA EYLDDRNTFR HSVVVPYEPP EVGSDCTTIH YNYMCNSSCM GGMNRRPILT IITLEDSSGN LLGRNSFEVR VCACPGRDRR TEEENFRKKG EPCPELPPGS SKRALPTTTT DSSPQTKKKP LDGEYFILKI RGRERFEMFR ELNEALELKD AQAEKEPGGS RAHSSYLKAK KGQSTSRHKK PMFKREGPDS D
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2. However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2.
基因功能參考文獻：
1. Suppressing expression of p53 was a required event in two assays of proliferative vitreoretinopathy. PMID: 22901751
2. These results suggest that p38 MAPK signal transduction pathway is critical to NO-induced chondrocyte apoptosis, and p38 plays a role by way of stimulating NF-kappaB, p53 and caspase-3 activation. PMID: 17468017
3. Our data indicate that exposure to rabbits to Pb(Ac)(2) caused a significant increase of apoptosis protein p53 and decrease in the antiapoptotic BCl2 proteins. PMID: 21112928
4. Chronically activated, monomeric PDGFRA induced prolonged activation of Akt and suppressed the level of p53. PMID: 21357737
5. In this study evidence is provided that exogenous PGF2alpha differentially modulates luteal expression of TP53 transcripts and protein depending on luteal stage. PMID: 20427144
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相關疾病：

p53 is found in increased amounts in a wide variety of transformed cells. p53 is frequently mutated or inactivated in many types of cancer.
亞細胞定位：

Cytoplasm. Nucleus. Nucleus, PML body. Endoplasmic reticulum. Mitochondrion matrix. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
蛋白家族：

P53 family
數據庫鏈接：

KEGG: ocu:100009292

STRING: 9986.ENSOCUP00000000989

UniGene: Ocu.1779