Recombinant Rabbit Calsequestrin-1 (CASQ1)

中文名稱：

Recombinant Rabbit Calsequestrin-1(CASQ1)
貨號：

CSB-YP004556RB
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Rabbit Calsequestrin-1(CASQ1)
貨號：

CSB-EP004556RB
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Rabbit Calsequestrin-1(CASQ1)
貨號：

CSB-EP004556RB-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Rabbit Calsequestrin-1(CASQ1)
貨號：

CSB-BP004556RB
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Rabbit Calsequestrin-1(CASQ1)
貨號：

CSB-MP004556RB
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

CASQ1
Uniprot No.：

P07221
別名：

CASQ1Calsequestrin-1; Aspartactin; Calsequestrin; skeletal muscle isoform; Laminin-binding protein
種屬：

Oryctolagus cuniculus (Rabbit)
蛋白長度：

Full Length of Mature Protein
表達區域：

29-395
氨基酸序列

EE GLDFPEYDGV DRVINVNAKN YKNVFKKYEV LALLYHEPPE DDKASQRQFE MEELILELAA QVLEDKGVGF GLVDSEKDAA VAKKLGLTEE DSIYVFKEDE VIEYDGEFSA DTLVEFLLDV LEDPVELIEG ERELQAFENI EDEIKLIGYF KNKDSEHYKA FKEAAEEFHP YIPFFATFDS KVAKKLTLKL NEIDFYEAFM EEPVTIPDKP NSEEEIVNFV EEHRRSTLRK LKPESMYETW EDDMDGIHIV AFAEEADPDG YEFLEILKSV AQDNTDNPDL SIIWIDPDDF PLLVPYWEKT FDIDLSAPQI GVVNVTDADS VWMEMDDEED LPSAEELEDW LEDVLEGEIN TEDDDDEDDD DDDDD
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction. Negatively regulates store-operated Ca(2+) entry (SOCE) activity.
基因功能參考文獻：
1. a mechanism for the observed in vitro and in vivo dynamic high-capacity and low-affinity Ca(2+)-binding activity of calsequestrin PMID: 22337878
2. Purified skeletal ryanodine receptors are similarly activated by purified triadin or purified junctin added to their luminal side, although a lack of competition indicated that the proteins act at independent sites. PMID: 19398037
亞細胞定位：

Endoplasmic reticulum. Sarcoplasmic reticulum. Sarcoplasmic reticulum lumen. Mitochondrion matrix. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side.
蛋白家族：

Calsequestrin family
組織特異性：

Detected in skeletal muscle (at protein level). Detected in skeletal muscle.
數據庫鏈接：

KEGG: ocu:100009095

STRING: 9986.ENSOCUP00000024484

UniGene: Ocu.6275