Recombinant Porphyromonas gingivalis Gingipain R2 (rgpB), partial

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文獻(xiàn)引用 (1)

中文名稱：

Recombinant Porphyromonas gingivalis Gingipain R2(rgpB),partial
貨號(hào)：

CSB-EP310587EYA
說(shuō)明書：

MSDS Datasheet
規(guī)格：

￥2328
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP310587EYA could indicate that this peptide derived from E.coli-expressed Porphyromonas gingivalis (strain ATCC BAA-308 / W83) rgpB.

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP310587EYA could indicate that this peptide derived from E.coli-expressed Porphyromonas gingivalis (strain ATCC BAA-308 / W83) rgpB.
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
引用文獻(xiàn)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

Greater than 90% as determined by SDS-PAGE.
基因名：

rgpB
Uniprot No.：

P95493
別名：

rgpB; prtRII; rgp2; PG_0506Gingipain R2; EC 3.4.22.37; Arg-gingipain; Gingipain 2; RGP-2
種屬：

Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
蛋白長(zhǎng)度：

Partial
來(lái)源：

E.coli
分子量：

43.3kDa
表達(dá)區(qū)域：

230-473aa
氨基酸序列

YTPVEEKENGRMIVIVPKKYEEDIEDFVDWKNQRGLRTEVKVAEDIASPVTANAIQQFVKQEYEKEGNDLTYVLLVGDHKDIPAKITPGIKSDQVYGQIVGNDHYNEVFIGRFSCESKEDLKTQIDRTIHYERNITTEDKWLGQALCIASAEGGPSADNGESDIQHENIIANLLTQYGYTKIIKCYDPGVTPKNIIDAFNGGISLANYTGHGSETAWGTSHFGTTHVKQLTNSNQLPFIFDVAC
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標(biāo)簽：

N-terminal 6xHis-SUMO-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
產(chǎn)品描述：

Porphyromonas gingivalis Gingipain R2/rgpB (CSB-EP310587EYA) with an N-terminal 6xHis-SUMO-tag is a partial-length recombinant protein generated in E.coli. The expressed region encodes the AA Tyr230-Cys473 of Porphyromonas gingivalis. This recombinant rgpB protein was evaluated by the LC-MS/MS analysis. The purity of this protein is up to 90% through SDS-PAGE analysis. This protein may be used to produce specific antibodies or in the studies of microbiology.

Arginine-specific gingipain 2 (rgpB) is an arginine-specific extra-cellular protease expressed on the surface of the oral pathogen Porphyromonas gingivalis outer membrane. It is one of the major viral virulence factors. Endogenous peptidylarginine deiminase enzyme (P.PAD), a virulence factor capable of citrullinating human and bacterial proteins, including auto-citrullination, interacts with rgpB. RgpB is essential for P. gingivalis to citrullinate peptides. Only after degradation by rgpB can P.PAD convert peptidylarginine into peptidylcitrulline.
Datasheet & COA：

Please contact us to get it.

引用文獻(xiàn)

Evaluation of circulating IgG antibodies against Porphyromonas gingivalis or its gingipains as serological markers of periodontitis and carriage of the bacterium L Massarenti,Journal of Periodontology,2024

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Thiol protease. Acts synergistically with RgpA to catalyze the maturation of fimbrial subunits, such as FimA. Its proteolytic activity is a major factor in both periodontal tissue destruction and in evasion of host defense mechanisms.
亞細(xì)胞定位：

Secreted.
蛋白家族：

Peptidase C25 family
數(shù)據(jù)庫(kù)鏈接：

KEGG: pgi:PG_0506

STRING: 242619.PG0506