Recombinant Porphyromonas gingivalis Gingipain R1 (rgpA), partial

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文獻(xiàn)引用 (1)

中文名稱(chēng)：

Recombinant Porphyromonas gingivalis Gingipain R1(rgpA),partial
品名簡(jiǎn)稱(chēng)：

Recombinant Porphyromonas gingivalis rgpA protein, partial
貨號(hào)：

CSB-EP338957PQP
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：

￥2328
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
引用文獻(xiàn)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

Greater than 90% as determined by SDS-PAGE.
基因名：

rgpA
Uniprot No.：

P28784
別名：

rgpA; rgp1Gingipain R1; EC 3.4.22.37; Arg-gingipain; Gingipain 1; RGP-1
種屬：

Porphyromonas gingivalis
蛋白長(zhǎng)度：

Partial
來(lái)源：

E.coli
分子量：

68.0kDa
表達(dá)區(qū)域：

228-720aa
氨基酸序列

YTPVEEKQNGRMIVIVAKKYEGDIKDFVDWKNQRGLRTEVKVAEDIASPVTANAIQQFVKQEYEKEGNDLTYVLLVGDHKDIPAKITPGIKSDQVYGQIVGNDHYNEVFIGRFSCESKEDLKTQIDRTIHYERNITTEDKWLGQALCIASAEGGPSADNGESDIQHENVIANLLTQYGYTKIIKCYDPGVTPKNIIDAFNGGISLVNYTGHGSETAWGTSHFGTTHVKQLTNSNQLPFIFDVACVNGDFLFSMPCFAEALMRAQKDGKPTGTVAIIASTINQSWASPMRGQDEMNEILCEKHPNNIKRTFGGVTMNGMFAMVEKYKKDGEKMLDTWTVFGDPSLLVRTLVPTKMQVTAPAQINLTDASVNVSCDYNGAIATISANGKMFGSAVVENGTATINLTGLTNESTLTLTVVGYNKETVIKTINTNGEPNPYQPVSNLTATTQGQKVTLKWDAPSTKTNATTNTARSVDGIRELVLLSVSDAPELLRS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標(biāo)簽：

N-terminal 6xHis-B2M-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
產(chǎn)品描述：

Porphyromonas gingivalis Gingipain R1 (rgpA)是一種來(lái)自口腔厭氧菌Porphyromonas gingivalis的蛋白，它是一種獨(dú)特的硫氨酸蛋白酶，具有重要的致病性。rgpA蛋白在牙周病的發(fā)病機(jī)制中起著重要作用。大量證據(jù)表明，RgpA有助于生物體的全部毒力，并通過(guò)破壞宿主免疫防御和破壞宿主組織來(lái)增加牙周病的風(fēng)險(xiǎn)。此外，rgpA蛋白也被用作研究牙周病發(fā)病機(jī)制的重要工具。

華美生物大腸桿菌表達(dá)系統(tǒng)所表達(dá)的rgpA重組蛋白，表達(dá)區(qū)域?yàn)?28-720aa，具有高穩(wěn)定性、高純度等特點(diǎn)，可用于相關(guān)科學(xué)研究。
Datasheet & COA：

Please contact us to get it.

引用文獻(xiàn)

Evaluation of circulating IgG antibodies against Porphyromonas gingivalis or its gingipains as serological markers of periodontitis and carriage of the bacterium L Massarenti,Journal of Periodontology,2024

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Thiol protease. Acts synergistically with RgpB to catalyze the maturation of fimbrial subunits, such as FimA. Its proteolytic activity is a major factor in both periodontal tissue destruction and in evasion of host defense mechanisms (Probable).
亞細(xì)胞定位：

Secreted.
蛋白家族：

Peptidase C25 family