Recombinant Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplast (DXR)

中文名稱：

Recombinant Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplast(DXR)
貨號：

CSB-YP808521EWP
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplast(DXR)
貨號：

CSB-EP808521EWP
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplast(DXR)
貨號：

CSB-EP808521EWP-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplast(DXR)
貨號：

CSB-BP808521EWP
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplast(DXR)
貨號：

CSB-MP808521EWP
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

DXR
Uniprot No.：

Q8IKG4
別名：

DXR; PF14_06411-deoxy-D-xylulose 5-phosphate reductoisomerase; apicoplastic; 1-deoxyxylulose-5-phosphate reductoisomerase; DOXP reductoisomerase; DXP reductoisomerase; EC 1.1.1.267
種屬：

Plasmodium falciparum (isolate 3D7)
蛋白長度：

Full Length of Mature Protein
表達區域：

73-488
氨基酸序列

AIKKPINV AIFGSTGSIG TNALNIIREC NKIENVFNVK ALYVNKSVNE LYEQAREFLP EYLCIHDKSV YEELKELVKN IKDYKPIILC GDEGMKEICS SNSIDKIVIG IDSFQGLYST MYAIMNNKIV ALANKESIVS AGFFLKKLLN IHKNAKIIPV DSEHSAIFQC LDNNKVLKTK CLQDNFSKIN NINKIFLCSS GGPFQNLTMD ELKNVTSENA LKHPKWKMGK KITIDSATMM NKGLEVIETH FLFDVDYNDI EVIVHKECII HSCVEFIDKS VISQMYYPDM QIPILYSLTW PDRIKTNLKP LDLAQVSTLT FHKPSLEHFP CIKLAYQAGI KGNFYPTVLN ASNEIANNLF LNNKIKYFDI SSIISQVLES FNSQKVSENS EDLMKQILQI HSWAKDKATD IYNKHNSS
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
基因功能參考文獻：
1. Innovative scaffolds with novel modes of action, improved efficacy and acceptable physiochemical/pharmacokinetic properties were computationally identified as potential inhibitors of 1-deoxy-d-xylulose 5-phosphate reductoisomerase for treatment of Falciparum malaria. PMID: 27650666
2. Data indicate that IspC (1-deoxy-D-xylulose 5-phosphate reductoisomerase) displays a high level of enantioselectivity for an alpha-substituted fosmidomycin derivative. PMID: 24032981
3. A three-dimensional model of the malarial drug target protein PfDXR was generated, and validated using structure-checking programs and protein docking studies. PMID: 20214634
4. These data indicate that deoxyxylulose 5-phosphate reductoisomerase is required for intraerythrocytic development of Plasmodium falciparum. PMID: 20018214
亞細胞定位：

Plastid, apicoplast.
蛋白家族：

DXR family
數據庫鏈接：

KEGG: pfa:PF14_0641