Recombinant Mouse Zinc finger protein ZPR1 (Znf259)

中文名稱：

小鼠Zpr1重組蛋白
貨號：

CSB-YP730787MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Zpr1重組蛋白
貨號：

CSB-EP730787MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Zpr1重組蛋白
貨號：

CSB-EP730787MO-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Zpr1重組蛋白
貨號：

CSB-BP730787MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Zpr1重組蛋白
貨號：

CSB-MP730787MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Zpr1
Uniprot No.：

Q62384
別名：

Zpr1; Zfp259; Znf259; Zinc finger protein ZPR1; Zinc finger protein 259
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區(qū)域：

1-459
氨基酸序列

MSASGAVQPG HPGAAVGPSP AAAASPATGP LFRPLSAEDE EQQPTEIESL CMNCYRNGTT RLLLTKIPFF REIIVSSFSC EHCGWNNTEI QSAGRIQDQG VRYTLTVRSQ EDMNREVVKT DSATTRIPEL DFEIPAFSQK GALTTVEGLI SRAISGLEQD QPTRRAVEGA IAERIDEFIG KLKDLKQMAS PFTLVIDDPS GNSFVENPHA PQKDNALVIT YYDRTPQQAE MLGLQAEAPE EKAEEEDLRN EVLQFNTNCP ECNAPAQTNM KLVQIPHFKE VIIMATNCEN CGHRTNEVKS GGAVEPLGTR ITLHITDPSD MTRDLLKSET CSVEIPELEF ELGMAVLGGK FTTLEGLLKD IRELVTKNPF TLGDSSNPDQ SEKLQEFSQK LGQIIEGKMK AHFIMNDPAG NSYLQNVYAP EDDPEMKVER YKRTFDQNEE LGLNDMKTEG YEAGLAPQR
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H(2)O(2)-induced neuronal cell death.
基因功能參考文獻：
1. Data suggest that the severity of disease correlates negatively with ZPR1 levels and ZPR1 may be a protective modifier of spinal muscular atrophy (SMA). PMID: 22422766
2. the interaction of ZPR1 and eEF1alpha PMID: 19966453
3. ZPR1 contributes to the regulation of survival motor neurons complexes and that it is essential for cell survival PMID: 15767679
4. ZPR1-deficient mice exhibit axonal pathology and neurodegeneration PMID: 16648254
相關(guān)疾病：

May contribute to the severity of spinal muscular atrophy by increasing spinal motor neurons degeneration.
亞細胞定位：

Nucleus. Cytoplasm. Nucleus, nucleolus. Cytoplasm, perinuclear region. Nucleus, gem. Nucleus, Cajal body. Cell projection, axon. Cell projection, growth cone.
蛋白家族：

ZPR1 family
組織特異性：

Expressed in brain. Expressed in the spinal cord motor neurons (at protein level). Expressed in spleen, liver, muscle, kidney and testis. Expressed in the frontal cortex, cornus ammonis, dentate gyrus of the hippocampus and in Purkinje cells of the cerebe
數(shù)據(jù)庫鏈接：

KEGG: mmu:22687

STRING: 10090.ENSMUSP00000117725

UniGene: Mm.17519