1. mRNA-binding protein tristetraprolin (TTP) is induced by iron deficiency and degrades mRNAs of mitochondrial Fe/S-cluster-containing proteins, specifically Ndufs1 in complex I and Uqcrfs1 in complex III, to match the decrease in Fe/S-cluster availability. PMID: 29915044
2. Expression of the RNA-binding protein, tristetraprolin (TTP) was down-regulated in response to calcineurin inhibition. PMID: 29723192
3. by utilizing Ttp-/- mice we demonstrated the in vivo anti-inflammatory role of Ttp in radiation pneumonitis. PMID: 28548957
4. Results suggest that RNA-binding proteins such as TTP are expressed and perhaps involved in the modulation of inflammation-induced pregnancy pathologies. PMID: 27732963
5. The authors found that the endogenous Zfp36 directly interacts with the cytoplasmic poly(A)-binding protein. Importantly, this interaction is required for the translational repression of Zfp36's target mRNAs in resolving inflammation. PMID: 28635594
6. degrades p28 to inhibit IL-27 production by macrophages and is thereby a negative regulator of the antitumour response PMID: 29021521
7. Results suggest that tristetraprolin (TTP) as a cytoskeletal regulator is required for spindle morphology/chromosome alignment and actin polymerization in oocytes. PMID: 27458159
8. RAS signaling can upregulate tumor cell PD-L1 expression through a mechanism involving increases in PD-L1 mRNA stability via modulation of the AU-rich element-binding protein tristetraprolin. PMID: 29246442
9. these data support the hypothesis that TTP plays a role in the post-transcriptional regulation of the ODC mRNA transcript. PMID: 27193233
10. Posttranscriptional gene regulation by TTP schedules the termination of the antimicrobial engagement of neutrophils. PMID: 28504646
11. the gain-of-function mutation of TTP impairs IL-10-mediated negative feedback control of macrophage function in vitro. PMID: 28265004
12. Studies indicate that mice lacking tristetraprolin (TTP) developed a spontaneous and pervasive inflammatory syndrome. PMID: 27911715
13. study uncovers a role of TTP as a suppressor of feedback inhibitors of inflammation and highlights the importance of fine-tuned TTP activity-regulation by MK2 in order to control the pro-inflammatory response PMID: 27220464
14. TTP is not involved in LPS-mediated destabilization of PLCbeta-2 mRNA in macrophages PMID: 28124257
15. Zinc Finger Protein 36 deficiency has profound effects on the splenic transcriptome. PMID: 26976640
16. Regulation of mRNAs by tristetraprolin appears to function as one of several critical post-transcriptional regulatory mechanisms controlling satellite cell homeostasis. PMID: 25815583
17. Tristetraprolin limits inflammatory cytokine production in tumor-associated macrophages in an mRNA decay-independent manner. PMID: 26183929
18. Dominant suppression of inflammation can be achieved via targeted mutation of the mRNA destabilizing protein tristetraprolin. PMID: 26002976
19. DUSP1 and tristetraprolin cooperate to regulate macrophage responses to lipopolysaccharide. PMID: 26019272
20. data shows TTP not only regulates the primary cellular response to innate immune stimuli, exemplified by TNF elaborated from macrophages, but also regulates expression of transcripts involved in the secondary response of mesenchymal cells to TNF stimulation PMID: 25657290
21. study provides a novel mechanism for the posttranscriptional regulation of TF expression, indicating that this is selectively regulated by PARP-14. PMID: 25293769
22. Intermedin attenuates macrophage foam-cell formation via tristetraprolin-mediated degradation of CD36 mRNA. PMID: 24253523
23. Results demonstrate that tristetraprolin acts as a negative regulator of IL-23 gene expression in mouse colon cancer cells and suggest its potential application as a novel therapeutic target to control IL-23-mediated tumor promotion. PMID: 24292977
24. our study reveals a novel pathway through which TTP suppresses IL-12 production in macrophages, resulting in suppression of Th1 cell differentiation. PMID: 23997224
25. Tight control of IL23 mRNA stability by TTP is critical to avoid severe inflammation. PMID: 23940256
26. Enhancing Zinc finger protein 36 expression in vascular endothelial cells, may attenuate atherosclrosis. PMID: 23559629
27. lactogenesis enhances Tristetraprolin expression PMID: 22968621
28. this study provided a detailed genetic roadmap for further understanding the regulatory effect of TTP in inflammatory pathways related to human diseases. PMID: 22995314
29. TTP-driven HIF-1alpha mRNA stabilization is crucial for cell migration. PMID: 22918951
30. MKP-1 suppressed Tristetraprolin expression by inhibiting p38 MAPK pathway. PMID: 23030431
31. tristetraprolin inhibits poly(A) tail synthesis by interacting with poly(A)-binding protein nuclear 1 in the nucleus to regulate expression of AU-rich element-containing mRNA PMID: 22844456
32. Expression of IL-10 is regulated posttranscriptionally by RNA-binding protein tristetraprolin (TTP), which destabilizes IL-10 mRNA in activated macrophages. PMID: 22865915
33. Myeloid cell TTP plays a critical role in protecting mice against lipopolysaccharide (LPS)-induced septic shock. PMID: 22491258
34. Data show that acetylcholine regulates muscle inflammation and cell survival, and point to Tristetraprolin and the choice of Mcl-1 mRNA polyadenylation sites as potential key players in muscle reactions to insults. PMID: 22093924
35. a novel function of TTP in repressing AU-rich mRNA translation PMID: 22203041
36. downregulates IL-6 gene expression at the post-transcriptional level by targeting AU-rich elements in the 3'UTR region PMID: 21457063
37. Data show that deletion of TTP completely abolishes IFN-gamma-mediated p19 mRNA degradation. PMID: 21515794
38. TTP is a master regulator of cytokine expression during homeostasis: without TTP, basal levels of inflammatory cytokines are left unchecked, and their increased production stimulates granulocyte production by committed progenitors entering the cell cycle. PMID: 21270394
39. MK2 phosphorylation reduces the ability of TTP to promote deadenylation by inhibiting the recruitment of CAF1 deadenylase in a mechanism that does not involve sequestration of TTP by 14-3-3. PMID: 20595389
40. The RNA binding protein tristetraprolin influences the activation state of murine dendritic cells. PMID: 19945750
41. TTP is expressed in response to muscle damage, precedes that of MyoD, and is detected 30 minutes after injury. The location of TTP in injured muscle suggests expression by satellite cells. PMID: 12077361
42. conclude that the physiological functions of TTP depend upon multiple regions of the TTP protein, that TTP has diverged functionally from TIS11b and TIS11d, and that modulation of TNFalpha responses may be a unique and important aspect of TTP function PMID: 12082611
43. The three-dimensional solution structure of the first domain of Nup475 has been determined by multidimensional nuclear magnetic resonance spectroscopy, revealing a novel fold around a central zinc ion. PMID: 12515557
44. TTP can be phosphorylated by JNK as well as by the other members of the greater MAP kinase family PMID: 12646273
45. induction by interleukin-4-stat6 signaling PMID: 14638848
46. tristetraprolin is phosphorylated by MAPKAP kinase 2 on in vivo sites including Ser178 PMID: 14688255
47. appears to be a low abundance, cytosolic protein in unstimulated cells and tissues, but once induced is relatively stable, in contrast to its very labile mRNA PMID: 15010466
48. mechanism by which the p38-MAPK/MAPKAP kinase-2 kinase cascade inhibits TTP-mediated degradation of AU-rich element-containing transcripts PMID: 15014438
49. stability of tristetraprolin mRNA is regulated by mitogen-activated protein kinase p38 and by tristetraprolin itself PMID: 15187092
50. Review. TTP-deficiency syndrome, its possible genetic modifiers, & the TTP-binding site in TNF-alpha & GM-CSF mRNAs are reviewed. The structure of the complex between RNA & one of the TTP-related proteins is used to model the TTP-RNA binding complex. PMID: 15535838

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KEGG: mmu:22695

STRING: 10090.ENSMUSP00000057815

UniGene: Mm.389856