Recombinant Mouse Stromal interaction molecule 2 (Stim2), partial

中文名稱：

小鼠Stim2重組蛋白
貨號：

CSB-YP022830MO1
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Stim2重組蛋白
貨號：

CSB-EP022830MO1
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Stim2重組蛋白
貨號：

CSB-EP022830MO1-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Stim2重組蛋白
貨號：

CSB-BP022830MO1
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Stim2重組蛋白
貨號：

CSB-MP022830MO1
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Stim2
Uniprot No.：

P83093
別名：

Stim2; Kiaa1482; Stromal interaction molecule 2
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx.
基因功能參考文獻：
1. Stim1 and Stim2 deficient B cells show an accelerated pace of affinity maturation but do not have dramatically impaired antibody production to T-independent antigen immunization PMID: 27572320
2. We found that STIM2 is required for the stable expression of both LTP and LTD at CA3-CA1 hippocampal synapses. Altered plasticity in Stim2 cKO mice is associated with subtle alterations in the shape and density of dendritic spines in CA1 neurons. PMID: 27544849
3. neutrophil cytokine production required STIM2, but not STIM1, at least in part as a result of redox regulation of cytokine gene expression PMID: 28724541
4. Expression of STIM2 protein rescued CaMKII activity and protected mushroom spines from Abeta42 oligomer toxicity in vitro and in vivo. PMID: 26275606
5. The data from this study indicate that upregulation of STIM2 and Orai2 is involved in the phenotypic transition of pulmonary arterial smooth muscle cells from a contractile state to a proliferative state. PMID: 25673771
6. Stim2 plays a moderate role in the development of autoinmune responses in a murine model of EAE, stimulating the proliferation of lymphocytes and the production of IFN-gamma/IL-17 by neuroantigen-specific T cells. PMID: 20028655
7. Using mice lacking STIM1 and its homologue STIM2, authors find that store-operated calcium entry in CD8(+) T cells is required to prevent the engraftment of melanoma and colon carcinoma cells and to control tumour growth. PMID: 23922331
8. STIM1 and STIM2-mediated store-operated Ca2+ influx, leading to efficient activation of NFAT (nuclear factor of activated T cells), is critical for the postselection maturation of agonist-selected T cells. PMID: 23499491
9. STIM1 and STIM2 protein deficiency in T lymphocytes underlies development of the exocrine gland autoimmune disease, Sjogren's syndrome. PMID: 22904194
10. show that endoplasmic reticulum calcium sensors STIM1- and STIM2-induced store-operated Ca(2+) influx is critical for B cell regulatory function PMID: 21530328
11. Absence of STIM2 in mouse embryonic fibroblasts results in a decreased store-operated calcium ion entry, although this inhibition is less pronounced than for STIM1. PMID: 20801505
12. both STIM1 and STIM2 are critical for T-cell function and autoimmunity in vivo. PMID: 21061435
13. STIM2 deficiency significantly delays onset and attenuates the clinical course of experimental allergic encephalitis. PMID: 20028655
14. Promote store-operated entry of calcium ions into T cells; required for the development and function of regulatory T cells. PMID: 18327260
15. Data demonstrate that cellular levels of STIM1 and STIM2, which are key players in capacitative Ca2+ entry, depend on presenilins. PMID: 19111578
16. show that STIM2, but not STIM1, is essential for capacitive Ca(2+) entry and ischemia-induced cytosolic Ca(2+) accumulation in neurons. PMID: 19843959
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亞細胞定位：

Endoplasmic reticulum membrane; Single-pass type I membrane protein.
數據庫鏈接：

KEGG: mmu:116873

STRING: 10090.ENSMUSP00000113174

UniGene: Mm.265985