Recombinant Mouse Somatoliberin (Ghrh)

中文名稱：

小鼠Ghrh重組蛋白
貨號：

CSB-YP009412MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Ghrh重組蛋白
貨號：

CSB-EP009412MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Ghrh重組蛋白
貨號：

CSB-EP009412MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Ghrh重組蛋白
貨號：

CSB-BP009412MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Ghrh重組蛋白
貨號：

CSB-MP009412MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Ghrh
Uniprot No.：

P16043
別名：

Ghrh; Somatoliberin; Growth hormone-releasing factor; GRF; Growth hormone-releasing hormone; GHRH
種屬：

Mus musculus (Mouse)
蛋白長度：

Cytoplasmic domain
表達區域：

31-72
氨基酸序列

HVDAIFTTNY RKLLSQLYAR KVIQDIMNKQ GERIQEQRAR LS
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone.
基因功能參考文獻：
1. Growth hormone-releasing hormone agonist markedly improve therapeutic angiogenesis in hindlimb ischemia by increasing the viability and mobility of mesenchymal stem cells. PMID: 26868211
2. The increased food intake observed in GHRH ablated animals is associated with increased locomotor and thermogenic activity. PMID: 25588992
3. exerts survival and antiapoptotic effects in skeletal muscle cells through the activation of anabolic pathways and the inhibition of proteolytic routes PMID: 26110916
4. In male mice GHRH deficiency brings about an increased physical activity and decreased anxiety- and depression-related behaviour, possibly related to increased TRH and decreased NE levels in the brain. PMID: 25028079
5. These data suggest that ghrelin increases GHRH neuron excitability by increasing action potential firing rates and decreasing the strength of GABA inputs, leading to enhanced GHRH release; and that obestatin counteracts ghrelin actions. PMID: 21777303
6. GHRH stimulated the NF-kappa b transcription factor, which is not only known to activate angiogenic factors but also the expression of genes involved in encoding enzymes in the prostaglandin-synthesis pathway such as COX-2 and the iNOS PMID: 20518847
7. Findings establish a novel ontogenetic profile for GHRH neurons and suggest previously undiscovered roles for peripubertal gonadal factors in establishing population size in both sexes. PMID: 21159856
8. treatment with a GHRH antagonist has positive effects on some aspects of aging, including an increase in telomerase activity. PMID: 21135231
9. Review. Growth hormone-releasing hormone (GHRH) is a hypothalamic hormone that is essential for normal expansion of the somatotrope lineage during pituitary development. PMID: 12511850
10. GHRH plays a crucial role in the development of experimental autoimmune encephalomyelitis. PMID: 12960295
11. Efficient production of mature GHRH from pro-GHRH is a stepwise process mediated predominantly by furin at the N-terminal cleavage site followed by PC1/3 at the C terminus PMID: 14684599
12. ablation of the GHRH gene causes isolated growth hormone deficiency in mice PMID: 15155578
13. growth hormone (GH) deficiency responds to GH-releasing hormone (GHRH), even when this factor is absent during intrauterine development PMID: 15564325
14. a splice variant of GHRH receptor designated SV1 may play a role in normal mouse physiology PMID: 16781787
15. co-localization of peptides and enzyme in GHRH-eGFP neurons displays a sexual dimorphism at 3-month of age for neurotensin, & at 8-month for tyrosine hydroxylase, while the total number of GHRH-eGFP neurons does not exhibit gender difference at either age PMID: 17137749
16. GHRH neurons are involved in aging of the GH axis. Aging had a subtle effect at the nerve terminal level in GHRH neurons, contrasting with the view that neuronal aging is accompanied by more widespread damage. PMID: 17328688
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亞細胞定位：

Secreted.
蛋白家族：

Glucagon family
數據庫鏈接：

KEGG: mmu:14601

STRING: 10090.ENSMUSP00000029172

UniGene: Mm.389327