Recombinant Mouse Sodium-dependent phosphate transport protein 2B (Slc34a2), partial

中文名稱：

小鼠Slc34a2重組蛋白
貨號：

CSB-YP887584MO
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Slc34a2重組蛋白
貨號：

CSB-EP887584MO
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Slc34a2重組蛋白
貨號：

CSB-EP887584MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Slc34a2重組蛋白
貨號：

CSB-BP887584MO
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Slc34a2重組蛋白
貨號：

CSB-MP887584MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Slc34a2
Uniprot No.：

Q9DBP0
別名：

Slc34a2; Npt2b; Sodium-dependent phosphate transport protein 2B; Sodium-phosphate transport protein 2B; Na(+)-dependent phosphate cotransporter 2B; Sodium/phosphate cotransporter 2B; Na(+)/Pi cotransporter 2B; NaPi-2b; Solute carrier family 34 member 2
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli.
基因功能參考文獻：
1. Npt2b deficiency did not affect Pi absorption within the range of Pi concentrations that normally occurs after meals. PMID: 29128884
2. This study validated the role of Npt2b in the pathogenesis of Pulmonary alveolar microlithiasis (PAM). PMID: 26560359
3. Overall, our preclinical results suggest that the ADC targeting NaPi2b provides an effective new therapy for the treatment of NSCLC and ovarian cancer and is currently undergoing clinical developments. PMID: 26156394
4. NaPi-IIb is the only luminal Na(+) -dependent Pi transporter in the murine ileum and its absence is fully compensated for in adult females by a mechanism involving the bone-kidney axis. PMID: 25827490
5. Knockdown of the sodium-dependent phosphate co-transporter 2b (NPT2b) suppresses lung tumorigenesis. PMID: 24194864
6. B-RAF increases the cell surface protein abundance and activity of the type II Na+-coupled phosphate transporters NaPi-IIa and NaPi-IIb. PMID: 24258620
7. that NHERF1 associates with NaPi-2b in enterocytes and regulates NaPi-2b adaptation. PMID: 22904329
8. Compared with wild-type uremic mice, Npt2b-deficient uremic mice had significantly lower levels of serum phosphate and attenuation of FGF23. PMID: 22859851
9. Npt2b is an important target for the prevention of hyperphosphatemia PMID: 21816756
10. NaPi-IIb was the predominantly expressed epithelial isoform of the sodium-inorganic phosphate cotransporter and was markedly overexpressed in the proximal region in the infertile knockout compared to the fertile heterozygous c-ros transgenic mouse PMID: 12773415
11. SGK1 stimulates the NaPi IIb, at least in part, by phosphorylating and thereby inhibiting Nedd4-2 binding to its target. PMID: 15044175
12. along the entire mouse small intestine, low-phosphate diet affects transcription and/or the stability of NaPi-IIb mRNA PMID: 15701623
13. NaPi-IIb expression was found to be mainly confined to the ileum in the small intestine PMID: 15701624
14. In the steady state, NaPi-IIb showed a curvilinear I-V relationship, with rate-limiting behavior only for depolarizing potentials. PMID: 17342377
15. Expression patterns of NaPi-IIb suggest that NaPi-IIb plays an important role in Pi absorption from maternal circulation. PMID: 19233126
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亞細胞定位：

Membrane; Multi-pass membrane protein.
蛋白家族：

SLC34A transporter family
組織特異性：

Highly abundant in the ileum of small intestine, whereas it is almost absent in the duodenum and in the jejunum.
數據庫鏈接：

KEGG: mmu:20531

STRING: 10090.ENSMUSP00000092380

UniGene: Mm.284891