Recombinant Mouse Semaphorin-3C (Sema3c)

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中文名稱：

Recombinant Mouse Semaphorin-3C (Sema3c)
品名簡稱：

Recombinant Mouse Sema3c protein
貨號：

CSB-BP720289MO
說明書：

MSDS Datasheet
規格：

￥2832
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

Greater than 85% as determined by SDS-PAGE.
生物活性：

Not Test
基因名：

Sema3c
Uniprot No.：

Q62181
別名：

Semaphorin-E (Sema E)
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
來源：

Baculovirus
分子量：

84.5 kDa
表達區域：

21-751aa
氨基酸序列

GSSQPQARVYLTFDELRETKTSEYFSLSHQQLDYRILLMDEDQDRIYVGSKDHILSLNINNISQEPLSVFWPASTIKVEECKMAGKDPTHGCGNFVRVIQTFNRTHLYVCGSGAFSPVCTYLNRGRRSEDQVFMIDSKCESGKGRCSFNPNVNTVSVMINEELFSGMYIDFMGTDAAIFRSLTKRNAVRTDQHNSKWLSEPMFVDAHVIPDGTDPNDAKVYFFFKERLTDNNRSTKQIHSMIARICPNDTGGQRSLVNKWTTFLKARLVCSVTDEDGPETHFDELEDVFLLETDNPRTTLVYGIFTTSSSVFKGSAVCVYHLSDIQTVFNGPFAHKEGPNHQLISYQGRIPYPRPGTCPGGAFTPNMRTTKDFPDDVVTFIRNHPLMYNSIYPIHRRPLIVRIGTDYKYTKIAVDRVNAADGRYHVLFLGTDRGTVQKVVVLPTNSSASGELILEELEVFKNHVPITTMKISSKKQQLYVSSNEGVSQVSLHRCHIYGTACADCCLARDPYCAWDGHSCSRFYPTGKRRSRRQDVRHGNPLTQCRGFNLKAYRNAAEIVQYGVRNNSTFLECAPKSPQASIKWLLQKDKDRRKEVKLNERIIATSQGLLIRSVQDSDQGLYHCIATENSFKQTIAKINFKVLDSEMVAVVTDKWSPWTWAGSVRALPFHPKDILGAFSHSEMQLINQYCKDTRQQQQLGEEPQKMRGDYGKLKALINSRKSRNRRNQLPES
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

C-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance.
基因功能參考文獻：
1. analyzed a complementary set of ligand-specific and tissue-specific mutants to show that neural crest-derived SEMA3C activates NRP1 in the cardiac outflow tract endothelium PMID: 26053665
2. No changes were observed in the binding of Sema3C to Nrp1-silenced B16(F10) cells, nor in its chemorepellent activity. PMID: 22082309
3. Data suggest that the formation and synaptic specificity of the GABAergic septohippocampal pathway relies on robust molecular mechanisms, independent of semaphorin 3C. PMID: 22092651
4. the guidance factor Semaphorin 3C, which is expressed by corpus callosum neurons, acts through the neuropilin 1 receptor to orient axons crossing through the corpus callosum. PMID: 19859539
5. Secreted sema3C favors cell survival and neuritogenesis of cultured cerebellar granule neurons PMID: 14622119
6. GATA-6 regulates semaphorin 3C and is required in cardiac neural crest for cardiovascular morphogenesis PMID: 16557299
7. sema 3C promotes glomerular endothelial cell proliferation, adhesion, directional migration, and tube formation in vitro by stimulating integrin phosphorylation and VEGF120 secretion PMID: 16940438
8. Taken together, our results reveal a molecular interaction between MMPs and semaphorins providing new insight into the molecular mechanism allowing axonal growth cone to respond to environmental guidance cues in the context of cortical development. PMID: 17021275
9. The endocytic pathway of neuropilin(Nrp)1 depends on its ligand: sema3C induces lipid raft-dependent endocytosis. PMID: 18723443
10. mutations in GATA6 are genetic causes of congenital heart diseases involving outflow tract defects, as a result of the disruption of the direct regulation of semaphorin 3C-plexin A2 signaling PMID: 19666519
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亞細胞定位：

Secreted.
蛋白家族：

Semaphorin family
數據庫鏈接：

KEGG: mmu:20348

STRING: 10090.ENSMUSP00000030568

UniGene: Mm.5071