Recombinant Mouse SWI/SNF complex subunit SMARCC1 (Smarcc1), partial

中文名稱：

小鼠Smarcc1重組蛋白
貨號：

CSB-YP021806MO
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Smarcc1重組蛋白
貨號：

CSB-EP021806MO
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Smarcc1重組蛋白
貨號：

CSB-EP021806MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Smarcc1重組蛋白
貨號：

CSB-BP021806MO
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Smarcc1重組蛋白
貨號：

CSB-MP021806MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Smarcc1
Uniprot No.：

P97496
別名：

Smarcc1; Baf155; Srg3; SWI/SNF complex subunit SMARCC1; BRG1-associated factor 155; SWI/SNF complex 155 kDa subunit; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1; SWI3-related protein; BAF155
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. May stimulate the ATPase activity of the catalytic subunit of the complex. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
基因功能參考文獻：
1. Conditional deletion of BAF155 causes impaired proliferation of olfactory neurons and defective axonogenesis in the developing olfactory epithelium. PMID: 27611684
2. BAF155 mediates the interaction between BAF complexes and H3K27demethylases, controlling the global level of H3K27me2/3 and ultimately the gene expression program in cortical development. PMID: 26655900
3. the role of BAF155 in late pre-implantation stages of mouse embryos PMID: 26952987
4. the increased frequency of Treg cells in the spinal cord of beta-actin-SRG3 Tg mice might induce the suppression of and accelerate the recovery from EAE symptoms. PMID: 26147219
5. Deletion of either Brg1 in the subependymal zone (SEZ) causes the progeny of adult neural stem cells to convert to the ependymal lineage within the SEZ while migrating neuroblasts convert to different glial lineages en route to or in the olfactory bulb. PMID: 23933087
6. Characterization of a missense mutation allele of the Smarcc1 gene (Smarcc1msp3 or Baf155msp3); lends new insight into the functions of the BAF chromatin remodeling complex during the critical stage of neural tube closure PMID: 24170322
7. we identify BAF155 as a substrate for arginine methyltransferase CARM1. PMID: 24434208
8. Wwp2 acts as a ubiquitin ligase of SRG3. PMID: 24365151
9. CHFR interacts with BRG1, SNF5, and BAF60a of the SWI/SNF-like BAF complex and ubiquitinates them to target for degradation through a proteasome-mediated pathway; SRG3 stabilizes these components by blocking their interaction with CHFR. PMID: 22285184
10. Our results establish a novel function of Srg3 in tumor suppression PMID: 20935679
11. report that members of the PBAF chromatin remodeling complex, including Smarca4/Brg1, Smarcb1/Baf47, Smarcc1/Baf155, and Smarce1/Baf57, are required for the repression of Nanog and other self-renewal gene expression upon mouse ESC (mESC) differentiation. PMID: 19785031
12. the SWI/SNF complex plays a critical role during T cell activation and subsequent immune responses PMID: 19910461
13. TCR signals result in GC desensitization in immature T cells by repressing SRG3 gene expression via Ras activation PMID: 15016814
14. SRG3 down-regulation has a role in E2A/HEB and Id3 proteins control of sensitivity to glucocorticoid-induced apoptosis in thymocytes PMID: 15016815
15. SRG3 expression in thymus is repressed by nitric oxide in an anti-apoptotic process PMID: 15187086
16. Results suggest that the multiple positive regulatory mechanisms of androgen receptor transactivation by SWI3-related gene product (SRG3) may be important for the rapid proliferation of prostate cells during prostate development and regeneration. PMID: 15923603
17. results suggest that diverse interactions between Sp1/Sp3 and Ets factors are crucial for the SRG3 gene expression PMID: 16288722
18. SRG3 is essential for extra-embryonic vascular development. PMID: 18206867
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亞細胞定位：

Nucleus. Cytoplasm.
蛋白家族：

SMARCC family
組織特異性：

Highly expressed in adult brain, testis and thymus.
數據庫鏈接：

KEGG: mmu:20588

STRING: 10090.ENSMUSP00000086094

UniGene: Mm.85410