Recombinant Mouse SHC-transforming protein 4 (Shc4)

中文名稱：

小鼠Shc4重組蛋白
貨號：

CSB-YP744202MO
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Shc4重組蛋白
貨號：

CSB-EP744202MO
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Shc4重組蛋白
貨號：

CSB-EP744202MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Shc4重組蛋白
貨號：

CSB-BP744202MO
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Shc4重組蛋白
貨號：

CSB-MP744202MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Shc4
Uniprot No.：

Q6S5L9
別名：

Shc4; Shcd; SHC-transforming protein 4; Rai-like protein; RaLP; SHC-transforming protein D; mShcD; Src homology 2 domain-containing-transforming protein C4; SH2 domain protein C4
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-626
氨基酸序列

MRERSQDSQA GLTLYVGLFG HLGMLHRTKY SRFRNESITS LDEGSPGGSV GNKGSSPPPY PALAPHLPTE DATVSSQESP TALCTLIPRM ASMKLANPIT FLGLKTFCLG TKQVSRLKLQ ENQDQTPSRP ASPESNLNRT GPAPAPDPDQ VGRRPTSLRP DTCPLPGPGE PSPRSKQDGP PLQHLLGNGL NYCVRYMGCI EVLQSMRSLD FGMRTQVTRE AISRLCEAVP GAHGAIKKRK APVKFLTTVL GKSNLQFSGM NIKLTVSTSS LTLMNLDNQQ IIANHQMQSI SFASGGDPDT TDYVAYVAKD PVNQRACHIL ECRSGMAQDV ISTIGQAFEL RFKQYLKNPS LNTWEREEVL VDGAPEDRDH DYYNSIPGKQ PPEGGISDVR IQAQATDQMA YCPIRCEKLC YLPGNSTCSG VYKNCMGRSR PIGIPHERAG QGDTPSLRHF WRVDLFDDPC YVNTQALQSM HSYAGNQSSA LPQGSPWHLG KAPETVQPGA TAKPGSALAL PHIRQQLWDE ECFHGKLSRG AAEKLLVKDG DFLVRESVTS PGQFVLSGLQ GGQAKHLLLV DPEGKVRTKD HVFDNVGHLI KYHMDNNLPI ISSGSEVRLK QPIRKYDNTG LLPPKK
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.
基因功能參考文獻：
1. Shc4 is an important modulator in the switch of key pathway(s) involved in determining epiblast stem cell identity. PMID: 22948967
2. The unique tissue distribution patterns of Shc proteins likely contribute to their complex tissue-specific signaling functions during embryogenesis. PMID: 21117147
3. A new member of the Shc family of docking proteins is characterised, which may mediate a specific aspect of signaling downstream of the MuSK receptor. PMID: 17452444
亞細胞定位：

Cell junction, synapse, postsynaptic cell membrane. Note=Colocalized with MUSK at the neuromuscular junction.
組織特異性：

Expressed in both brain and skeletal muscle; widely expressed in brain namely olfactory bulb, cortex, hippocampus, striatum, thalamus, and brain stem (at protein level). Only expressed in melanomas. Weakly expressed in normal melanocytes and benign nevi.
數據庫鏈接：

KEGG: mmu:271849

STRING: 10090.ENSMUSP00000043146

UniGene: Mm.425101