Recombinant Mouse Rho GTPase-activating protein 18 (Arhgap18)

中文名稱：

Recombinant Mouse Rho GTPase-activating protein 18(Arhgap18)
貨號：

CSB-YP810360MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Rho GTPase-activating protein 18(Arhgap18)
貨號：

CSB-EP810360MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Rho GTPase-activating protein 18(Arhgap18)
貨號：

CSB-EP810360MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Rho GTPase-activating protein 18(Arhgap18)
貨號：

CSB-BP810360MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Rho GTPase-activating protein 18(Arhgap18)
貨號：

CSB-MP810360MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Arhgap18
Uniprot No.：

Q8K0Q5
別名：

Arhgap18; Rho GTPase-activating protein 18; Rho-type GTPase-activating protein 18
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-663
氨基酸序列

MNWLSSSSGV VLTAYHPSGK DQVAGDSHVK GGDEATSSRR YGQYTINQEG STKVPERPPF DRSSSQDSLD ESMEAYWTEL ENIKRSNENR QEGQEAIVVK EPDEGELEEE WLKEAGLSNL FGESIDDPQE SILFLSTLTR TQAAAVQKRV ETVSQTLRKK NKQHHIRDVR DIFAQQREAQ EKPPDDSDLR SVRTNENKGQ GKDDQPSSGA VDSKEQISRV PEDTPASETD INLEVSFAEQ AVNQKEFSKE RTQKISSNDS LPSFRLPKDK TGTTRIGDLA PQDMKKVCSL SLIELTALYD VLGLEFKQQK AVKIKTRDSG LFGIPLTILL EQDQRKVPGT RIPLIFQKLI SRIEEGSLET EGLLRIPGAA MRIKNLCQEL EAKFYEGTFN WESVKQHDAA SLLKLFLREL PQPLLSMEYL KAFQAVQNLP TRKEQLQALN LLVILLPDAN RDTLKALLEF LQRVIDNKEK NKMTAGNVAM VMAPNLFMCH TLGLKSSEQR EFEMAAGTAN VMHLLIRYQK ILWTIPKFIV IQVRKQNIEN QKKERKAMKK LLKKMAYDRE KHEKQDKTAN GADVPQGVIR VQAPHLSKVS MAIQLTEELK ASDVLARFLS QESGVAQTLK KGEVFLYEIG GNIGERCLDD DTHMKDLYQL NPNAEWVIKS KPV
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state. Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1. Regulates cell shape, spreading, and migration.
基因功能參考文獻：
1. ARHGAP 18 was identified as a novel protective gene against thoracic aortic aneurysm formation. PMID: 28701309
2. In endothelial cells, ARHGAP18 may act as a significant regulator of vascular homeostasis. PMID: 28251925
3. Results describe ARHGAP18 as a novel negative regulator of sprouting by acting dualistically to limit tip cell formation and to maintain junctional integrity. PMID: 25425145
亞細胞定位：

Cytoplasm.
組織特異性：

Widely expressed: expressed in most organs, except small intestine.
數據庫鏈接：

KEGG: mmu:73910

STRING: 10090.ENSMUSP00000044834

UniGene: Mm.356496