1. the cardiovascular response of Ramp1(-/-), Ramp2(+/-), Ramp3(-/-), Ramp1(-/-)/Ramp3(-/-) double-knockout (dKO), and Calcrl(+/-) mice to AM and CGRP were compared to wildtype mice.These results suggest that the hypotensive effect of AM is primarily mediated through the CLR/RAMP1 heterodimer, but that AM signaling via CLR/RAMP2 and CLR/RAMP3 also contributes to some hypotensive action. PMID: 27940069
2. RAMP1 signaling improves lymphedema and accelerates lymphangiogenesis associated with reduced recruitment of pro-inflammatory macrophages. PMID: 29078910
3. RAMP1 exerted mucosal protection in DSS-induced colitis via attenuation of recruitment of inflammatory cells and of pro-inflammatory cytokines. PMID: 27513455
4. Together, these data indicate that signaling through RAMP1 and CLR plays a role in mediating asthma pathology PMID: 25010197
5. multiple NKX3.1 binding sites were found in the RAMP1 locus in human prostate cancer cells and in the normal mouse prostate. PMID: 23867798
6. Data indicate that IL-17 production is suppressed in RAMP1-deficient mice in the experimental autoimmune encephalomyelitis (EAE) model and RAMP1-deficient mice are completely resistant to EAE. PMID: 22843730
7. Data indicate that the lack of an intact CGRP receptor component RAMP1 resulted in an increased recruitment and activation of neutrophils. PMID: 22656887
8. Data show that mechanical ventilation reduced the expression of receptor activity-modifying protein RAMP3, but not of intermedin (IMD), calcitonin receptor-like receptor (CRLR), and RAMP1 and RAMP2. PMID: 22563471
9. significantly diminished intestinal peristalsis was observed by the allergy induction in RAMP1-deficient mice compared with WT mice. PMID: 21683059
10. These findings suggest that RAMP1 may be a new therapeutic target to regulate CGRP-mediated effects during disease including pathophysiological states in which Ang II plays a major role. PMID: 20814003
11. Co-expression of RAMP1 and CRLR reconstituted a CGRP receptor that was able to activate the pheromone-signaling pathway with pharmacological properties similar to those observed previously in mammalian cells. PMID: 11733510
12. role in cell surface expression of CRLR/RAMP heterodimeric receptors PMID: 11854283
13. The mouse cDNA for RAMP1 was cloned and we examined the signal transduction mechanism through the CGRP receptor. mRAMP1 is a 148-amino acid single membrane-spanning protein with a short cytoplasmic portion. PMID: 12147211
14. These findings suggest that tissue specificity of RAMP-1 gene expression is mediated by a negative acting transcription factor that represses RAMP-1 gene expression in non-RAMP-1 expressing tissues. PMID: 15790393
15. These results indicate that CGRP signaling through CLR/RAMP1 receptors plays a crucial role in the regulation of both blood pressure by vascular relaxation and proinflammatory cytokine production from dendritic cells. PMID: 17923674
16. CTR is not only down regulated by signaling through the CTR but also by the peptides signaling through calcitonin receptor-like receptor, and receptor activity modifying proteins PMID: 18384073
17. These data suggest that hypersensitivity to CGRP could be a potential mechanism underlying central sensitization in migraine and point to CGRP-receptor antagonists as a possible therapy for other pain disorders. PMID: 19628434

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KEGG: mmu:51801

STRING: 10090.ENSMUSP00000095253

UniGene: Mm.3272