Recombinant Mouse Ragulator complex protein LAMTOR3 (Lamtor3)

中文名稱：

小鼠Lamtor3重組蛋白
貨號：

CSB-YP013477MO
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Lamtor3重組蛋白
貨號：

CSB-EP013477MO
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Lamtor3重組蛋白
貨號：

CSB-EP013477MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Lamtor3重組蛋白
貨號：

CSB-BP013477MO
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Lamtor3重組蛋白
貨號：

CSB-MP013477MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Lamtor3
Uniprot No.：

O88653
別名：

Lamtor3; Map2k1ip1; Mapbp; Mapksp1Ragulator complex protein LAMTOR3; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3; MEK-binding partner 1; Mp1; Mitogen-activated protein kinase kinase 1-interacting protein 1; Mitogen-activated protein kinase scaffold protein 1
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-124
氨基酸序列

MADDLKRFLY KKLPSVEGLH AIVVSDRDGV PVIKVANDSA PEHALRPGFL STFALATDQG SKLGLSKNKS IICYYNTYQV VQFNRLPLVV SFIASSSANT GLIVSLEKEL APLFEELIKV VEVS
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
基因功能參考文獻：
1. We show an essential function for late endosomes carrying the p14-MP1 (LAMTOR2/3) complex in focal adhesion dynamics. PMID: 24841562
2. Data indicate that LAMTOR3 protein is stabilized by associating with LAMTOR2. PMID: 23653355
3. A genome-wide RNAi screen in mouse embryonic stem cells identifies Mp1 as a key mediator of differentiation. PMID: 22143885
4. MP1 and the MP1*P14 complex have the potential to differentially modulate activating and inhibiting signals in the Raf-MKK1/2-ERK1/2 pathway. PMID: 17254543
亞細胞定位：

Late endosome membrane; Peripheral membrane protein; Cytoplasmic side.
蛋白家族：

LAMTOR3 family
數據庫鏈接：

KEGG: mmu:56692

STRING: 10090.ENSMUSP00000136999

UniGene: Mm.331392