Recombinant Mouse RNA-binding protein 20 (Rbm20), partial, partial

中文名稱：

小鼠Rbm20重組蛋白
貨號：

CSB-YP659743MO
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Rbm20重組蛋白
貨號：

CSB-EP659743MO
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Rbm20重組蛋白
貨號：

CSB-EP659743MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Rbm20重組蛋白
貨號：

CSB-BP659743MO
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Rbm20重組蛋白
貨號：

CSB-MP659743MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
問答及客戶評論
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Rbm20
Uniprot No.：

Q3UQS8
別名：

Rbm20; RNA-binding protein 20; RNA-binding motif protein 20
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

問答及客戶評論

■ 常見問題解答

Is this protein functionally-folded? And after transfection through nucleovector does it function like a native protein?

Thanks for your inquiry. This protein has a lot of phosphorylation modifications, the expression of the insect system can effectively fold a wide range of post-translational modifications, and we are purified under mild conditions, theoretically it can be folded correctly, but we did not detect it, so we can not guarantee.

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靶點詳情

功能：

RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes involved in cardiac development. Regulates splicing of TTN (Titin).
基因功能參考文獻：
1. Reducing RBM20 activity improves diastolic dysfunction and cardiac atrophy. PMID: 27889803
2. Inhibition of the RNA binding motif-20-based titin splicing system upregulates compliant titins, which improves diastolic function and exercise tolerance in the transverse aortic constriction/deoxycorticosterone acetate model PMID: 27630136
3. Study demonstrates that Rbm20 is expressed in early cardiogenesis and functions in the patterning of cardiac gene expression. PMID: 24584570
4. Nuclear retention domains have been identified in RBM20 which is a nuclear protein regulating alternative splicing of expressed genes. PMID: 23886709
亞細胞定位：

Nucleus.
組織特異性：

Predominantly expressed in striated muscle, with highest expression in the heart. In differentiating myoblasts, expression correlates with sarcomere assembly: expression peaks when alpha-actinin is localized mainly in mature Z bodies within the nascent my
數據庫鏈接：

KEGG: mmu:73713

STRING: 10090.ENSMUSP00000129447

UniGene: Mm.313695