Recombinant Mouse Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial (Clpp)

中文名稱：

Recombinant Mouse Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial(Clpp)
貨號：

CSB-YP005577MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial(Clpp)
貨號：

CSB-EP005577MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial(Clpp)
貨號：

CSB-EP005577MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial(Clpp)
貨號：

CSB-BP005577MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial(Clpp)
貨號：

CSB-MP005577MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Clpp
Uniprot No.：

O88696
別名：

ClppATP-dependent Clp protease proteolytic subunit; mitochondrial; EC 3.4.21.92; Endopeptidase Clp
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達區域：

53-272
氨基酸序列

PLIPIVVE QTGRGERAYD IYSRLLRERI VCVMGPIDDS VASLVIAQLL FLQSESNKKP IHMYINSPGG VVTAGLAIYD TMQYILNPIC TWCVGQAASM GSLLLAAGSP GMRHSLPNSR IMIHQPSGGA RGQATDIAIQ AEEIMKLKKQ LYNIYAKHTK QSLQVIESAM ERDRYMSPME AQEFGILDKV LVHPPQDGED EPELVQKETA TAPTDPPAPT ST
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates. Cleaves PINK1 in the mitochondrion.
基因功能參考文獻：
1. we demonstrate that a strong mitochondrial cardiomyopathy and diminished respiration due to DARS2 deficiency can be alleviated by the loss of CLPP, leading to an increased de novo synthesis of individual OXPHOS subunits. PMID: 27154400
2. The authors present evidence that mammalian CLPP has an essential role in determining the rate of mitochondrial protein synthesis by regulating the level of mitoribosome assembly. PMID: 27797820
3. Novel effects of ClpP on mitochondrial morphology, cell proliferation and protein translation pathways in muscle cells. PMID: 26721594
4. Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors. PMID: 23851121
5. The correlative effect of Lon and ClpP upregulation on loss of mitochondrial Fe-S proteins during the progression of the disease may suggest that Fe-S proteins are potential targets of Lon and ClpP proteases in FRDA. PMID: 19154341
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亞細胞定位：

Mitochondrion matrix.
蛋白家族：

Peptidase S14 family
組織特異性：

Detected in liver (at protein level). High levels found in heart, liver and skeletal muscle.
數據庫鏈接：

KEGG: mmu:53895

STRING: 10090.ENSMUSP00000002735

UniGene: Mm.287892