Recombinant Mouse Protein 4.1 (Epb41), partial

中文名稱：

小鼠Epb41重組蛋白
貨號：

CSB-YP007706MO
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Epb41重組蛋白
貨號：

CSB-EP007706MO
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Epb41重組蛋白
貨號：

CSB-EP007706MO-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Epb41重組蛋白
貨號：

CSB-BP007706MO
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Epb41重組蛋白
貨號：

CSB-MP007706MO
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Epb41
Uniprot No.：

P48193
別名：

Epb41; Epb4.1; Kiaa4056Protein 4.1; P4.1; 4.1R; Band 4.1
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase.
基因功能參考文獻：
1. 4.1R plays an important role in transporting 5-aminolevulinic acid into cells via at least partly interaction with GAT1 and GAT2 transporters in 5-ALA-PDT. PMID: 28881432
2. This suggests that 4.1R may influence myogenesis by preventing VHL-mediated myogenin degradation. PMID: 27780863
3. The proportion of 4.1R-positive cells was significantly higher in the HF group than in the controls, which was confirmed by the positive mRNA expression of 4.1R. 4.1R localized mostly to the plasma membrane of myocardial cells and was upregulated with the progression of HF. This suggests that 4.1R may be associated with HF progression. PMID: 27323040
4. suggest that 4.1R can prevent pathogenic autoimmunity in MS/EAE progression by suppressing the CD4(+) T cell activation PMID: 25243644
5. a functional role for 4.1R in small intestinal calcium absorption through regulation of membrane expression of PMCA1b. PMID: 23460639
6. At the intercalated disc 4.1R does not colocalise with the adherens junction protein, beta-catenin, but does overlap with the other plasma membrane signalling proteins, the Na/K-ATPase and the Na/Ca exchanger NCX1. PMID: 22429617
7. Cell adhesion and signaling pathways regulated by alphavbeta8 integrin and Band 4.1B are essential for normal formation and function of the heart during embryogenesis. PMID: 21181944
8. A conserved exonic splicing silencer element (CE(16)) in protein 4.1R exon 16 (E16) interacts with hnRNP A/B proteins & plays a role in repression of E16 splicing during early erythropoiesis PMID: 12426391
9. We speculate that over the repetitive cycles of heart muscle contraction and relaxation, 4.1R is likely to locate, support, and coordinate functioning of key membrane-bound macromolecular assemblies.[Epb41] PMID: 15834631
10. These results suggest that erythroid protein 4.1 plays a major role in volume regulation and physiologically downregulates Na/H exchange in mouse erythrocytes. PMID: 16774987
11. 4.1R organizes a macromolecular complex of skeletal and transmembrane proteins at the junctional node. PMID: 18524950
12. Cytoskeletal protein 4.1R affects repolarization and regulates calcium handling in the heart. PMID: 18787192
13. 4.1R knockout mice exhibit bradycardia, prolonged action potentials & QT intervals, and anomalous ion channel activities. 4.1R has a role in the cellular accumulation of NaV1.5. Review. PMID: 19272819
14. 4.1R gene expression involves transcriptional regulation coupled with a complex splicing regulatory network. PMID: 19729518
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亞細胞定位：

Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.
數(shù)據(jù)庫鏈接：

KEGG: mmu:269587

STRING: 10090.ENSMUSP00000030739

UniGene: Mm.30038