Recombinant Mouse Prostacyclin receptor (Ptgir), partial

中文名稱：

小鼠Ptgir重組蛋白
貨號：

CSB-YP018981MO1
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Ptgir重組蛋白
貨號：

CSB-EP018981MO1
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Ptgir重組蛋白
貨號：

CSB-EP018981MO1-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Ptgir重組蛋白
貨號：

CSB-BP018981MO1
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Ptgir重組蛋白
貨號：

CSB-MP018981MO1
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Ptgir
Uniprot No.：

P43252
別名：

Ptgir; Prostacyclin receptor; Prostaglandin I2 receptor; PGI receptor; PGI2 receptor; Prostanoid IP receptor
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.
基因功能參考文獻：
1. results provide evidence that PGI2/IP signaling suppresses the STAT6-independent pathway of allergic airway inflammation PMID: 27456482
2. Data (including data from studies using transgenic mice, an murine experimental model of diabetes, and mouse/human cell lines) suggest prostaglandin I2 receptor (Ptgir) is involved in insulin secretion in pancreatic beta-cells and in permselectivity in glomerular podocytes; the mechanism appears to involve regulation of post-translational phosphorylation of nephrin. PMID: 26868296
3. Deletion of the I prostanoid receptor had no effect on the attenuation of atherogenesis by mPGES-1 deletion in the low-density lipoprotein receptor knockout mice. PMID: 27440004
4. Prostacyclin promotes the up-regulation of Nox4 in endothelial cells, which opens up a novel strategy that protects and enhances endothelial cell functions in cardiovascular disease, such as repair after myocardial infarction or other ischemic conditions. PMID: 24450852
5. Its signaling increase cAMP concentration, which prototes sysnesis of HGF, causing angiogenesis. PMID: 24292413
6. an essential role of the COX-2/PGI2 receptor axis in the cardioprotection afforded by the late ischemic preconditioning PMID: 22844439
7. findings suggest the IP receptor might maintain an angiogenic switch in the "on" state in tumor endothelial cells (TEC); suggest that the IP receptor is a TEC-specific marker and might be a useful therapeutic target PMID: 22380928
8. PGI2-induced PPAR delta activation accelerates blastocyst hatching in mice PMID: 21511721
9. For the first time these results show that activation of prostaglandin I2 receptor can attenuate damage following cerebral ischemia. PMID: 20621166
10. identify PGI(2)-prostaglandin I2 receptor as an important pathway for inhibiting allergic pulmonary inflammation by controlling recruitment of CD4(+) Th2 cells into the inflammatory site PMID: 17947695
11. The prostacyclin/IP pathway suppresses cardiac fibrosis, at least partly, by inducing CREB phosphorylation. PMID: 20403362
12. Prostaglandin I2 receptor signaling promotes T helper cell type (Th)1 differentiation through a cyclic adenosine monophosphate (AMP)-protein kinase A pathway, thereby initiating acquired cutaneous immune responses. PMID: 20400695
13. The prostaglandin I(2)-IP system is essential for EPCs to accomplish their function and plays a critical role in the regulation of vascular remodeling. PMID: 20007911
14. Results identify the cyclooxygenase-2 gene as a target of APOE signaling, link HDL and APOE to prostacyclin receptor IP action, and describe a potential new basis for the cardioprotective effect of HDL and APOE. PMID: 14966570
15. results suggest that signaling through IP has antiviral effects while protecting against respiratory syncytial virus-induced illness PMID: 15367596
16. The -CSLC motif of the IP is a direct target for inhibition by the FTI SCH66336, and in the presence of strong farnesyltransferase inhibition, the IP does not undergo compensatory geranylgeranylation. PMID: 15469414
17. Baseline systolic blood pressurewas significantly lower in the IP(-/-) group than in the IP(+/+) mice. PMID: 15635218
18. IP plays a suppressive role in the development of pressure overload-induced cardiac hypertrophy via the inhibition of both cardiomyocyte hypertrophy and cardiac fibrosis PMID: 15983244
19. IP receptors play an important role in preimplantation embryo development and mediate the embryo's response to exogenous PGI(2) PMID: 17905746
20. ONO-54918-07 mimics the effect of PGE1(prostaglandin E1), supporting the notion that the PGE1 effect on NG108-15 cells is mediated by prostacyclin receptors. PMID: 17952410
21. prostacyclin receptor knockout mice showed normal pain behavior in all tests PMID: 18938093
22. PGIS/ IP transgenic animals with lung-specific PPARgamma overexpression also developed fewer lung tumors. PMID: 19138979
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亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 1 family
數據庫鏈接：

KEGG: mmu:19222

STRING: 10090.ENSMUSP00000122080

UniGene: Mm.287572