Recombinant Mouse Proepiregulin (Ereg), partial

中文名稱：

Recombinant Mouse Proepiregulin (Ereg), partial
品名簡(jiǎn)稱：

Recombinant Mouse Ereg protein, partial
貨號(hào)：

CSB-MP730741MOr10
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：

￥708
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

Greater than 95% as determined by SDS-PAGE.
生物活性：

Not Test
基因名：

Ereg
Uniprot No.：

Q61521
別名：

Ereg
種屬：

Mus musculus (Mouse)
蛋白長(zhǎng)度：

Partial
來(lái)源：

Mammalian cell
分子量：

73.5 kDa
表達(dá)區(qū)域：

56-101aa
氨基酸序列

VQITKCSSDMDGYCLHGQCIYLVDMREKFCRCEVGYTGLRCEHFFL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標(biāo)簽：

C-terminal 10xHis-HSA-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation. Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation.
基因功能參考文獻(xiàn)：
1. Collectively, these data indicate that Yap-induced Epiregulin signaling promotes the identity of submandibular gland ductal progenitors and that removal of nuclear Yap by Lats1/2-mediated signaling is critical for proper ductal maturation. PMID: 28492365
2. High expression of EREG is associated with lung carcinogenesis. PMID: 28472347
3. The lack of the growth factor Ereg results in significantly reduced lung tumor development in a primary chemically induced tumor promotion model compared to wildtype controls (Ereg+/+ mice). PMID: 26894620
4. three-dimensional structure of the EPR antibody (the 9E5(Fab) fragment) in the presence and absence of EPR PMID: 26627827
5. Epiregulin promotes the proliferation of liver progenitor cells and DNA synthesis by hepatocytes and is upregulated in the serum of patients with liver injury. PMID: 24812054
6. EREG and tumor-associated fibroblasts play a crucial role in controlling tumor growth in colitis-associated neoplasms. PMID: 23549083
7. Epiregulin can effectively mature isolated cumulus-oocyte complexes, but fails as a substitute for the hCG/epidermal growth factor stimulus on cultured follicles. PMID: 19321658
8. Epiregulin plays a critical role in immune/inflammatory-related responses of keratinocytes and macrophages. PMID: 15365177
9. Data suggest that epiregulin (Ereg) deficiency does not alter intestinal cancer susceptibility, but that Ereg-null mice are highly susceptible to cancer-predisposing intestinal damage caused by oral dextran sulfate sodium. PMID: 15456865
10. Castration leads to adaptive increase in the concentrations of a subset of growth factors from the EGF network in the androgen sensitive CWR22 prostate cancer xenograft PMID: 15651060
11. Epiregulin may have a critical role in the regulation of peptidoglycan-mediated interleukin-6 production in antigen presenting cells and innate immunity. PMID: 16182244
12. Epiregulin appears as a new growth and insulinotropic factor in pancreatic beta cell lines. PMID: 16338791
13. Mycobacterium tuberculosis-infected macrophages play a pivotal role in TB-induced carcinogenesis by inducing DNA damage and by the production of a potent epidermal growth factor epiregulin responsible for squamous metaplasia and tumorigenesis. PMID: 19330024
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亞細(xì)胞定位：

[Epiregulin]: Secreted, extracellular space.; [Proepiregulin]: Cell membrane; Single-pass type I membrane protein.
數(shù)據(jù)庫(kù)鏈接：

KEGG: mmu:13874

STRING: 10090.ENSMUSP00000031324

UniGene: Mm.4791