Recombinant Mouse Probetacellulin (Btc), partial

中文名稱：

Recombinant Mouse Probetacellulin (Btc), partial
品名簡稱：

Recombinant Mouse Btc protein, partial
貨號：

CSB-YP002853MO
說明書：

MSDS Datasheet
規格：

￥1656
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

Greater than 90% as determined by SDS-PAGE.
生物活性：

Not Test
基因名：

Btc
Uniprot No.：

Q05928
別名：

Btc;Bcn
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
來源：

Yeast
分子量：

11.1 kDa
表達區域：

32-111aa
氨基酸序列

DGNTTRTPETNGSLCGAPGENCTGTTPRQKVKTHFSRCPKQYKHYCIHGRCRFVVDEQTPSCICEKGYFGARCERVDLFY
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

C-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.
基因功能參考文獻：
1. Betacellulin promotes the proliferation of corneal epithelial stem cells through the phosphorylation of Erk1/Erk2. PMID: 29331377
2. The results of this study suggested a novel regulatory role of Btc in axon-Schwann cell interactions involved in myelin formation and nerve repair. PMID: 28139851
3. BTC induces expansion of neural stem cells and neuroblasts, and promotes neurogenesis in the olfactory bulb and dentate gyrus. PMID: 22232668
4. Betacellulin exerts proliferative activity on beta cells through the activation of ErbB-1 and ErbB-2 receptors PMID: 21897861
5. BTC overexpression enhances glucose-induced insulin secretion in Mesenchyma Stem Cells PMID: 20836700
6. Betacellulin protects from pancreatitis by activating stress-activated protein kinase. PMID: 20038432
7. Excess of betacellulin exerts no deleterious effects on the structure or function of the male reproductive tract in mice. PMID: 19931240
8. structure of the BTC gene PMID: 12031500
9. Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling. PMID: 12773386
10. Mice overexpressing BTC exhibit high early postnatal mortality, reduced body weight gain, impaired longitudinal growth, cataract, retinal and bone abnormalities, and lung disease. PMID: 16179416
11. identified hitherto unknown effects of betacellulin (BTC) overabundance in reproduction and suggests BTC as a novel candidate protein for the modulation of fertility. PMID: 17914071
12. role of BTC in the regulation of epidermal homeostasis, hair follicle morphogenesis and cycling, and wound angiogenesis PMID: 17960175
13. Overexpression of BTC results in an EGFR-dependent upregulation of cortical bone mass in the appendicular skeleton of mice. PMID: 19049329
14. Long-term BTC overabundance does not alter pancreatic islet structure and beta-cell mass, but enhances glucose-induced insulin secretion in vivo as well as in vitro. PMID: 19100309
15. Reversal of streptozotocin-induced hyperglycemia by continouous supply of Btc. PMID: 19378417
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亞細胞定位：

[Betacellulin]: Secreted, extracellular space.; [Probetacellulin]: Cell membrane; Single-pass type I membrane protein.
組織特異性：

Found in several mouse tissues including kidney, uterus and liver, as well as in beta tumor cell line and MCF-7 cells. It is not detected in the brain.
數據庫鏈接：

KEGG: mmu:12223

STRING: 10090.ENSMUSP00000112765

UniGene: Mm.2024